TY - JOUR
T1 - Graphene nanoplatelet and graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2
AU - De Maio, Flavio
AU - Palmieri, Valentina
AU - Babini, Gabriele
AU - Augello, Alberto
AU - Palucci, Ivana
AU - Perini, Giordano
AU - Salustri, Alessandro
AU - Spilman, Patricia
AU - De Spirito, Marco
AU - Sanguinetti, Maurizio
AU - Delogu, Giovanni
AU - Rizzi, Laura Giorgia
AU - Cesareo, Giulio
AU - Soon-Shiong, Patrick
AU - Sali, Michela
AU - Papi, Massimiliano
N1 - Funding Information:
This paper is in memory of G.B., who died prematurely. Work presented in this paper has been partially supported by Directa Plus Srl. Università Cattolica del Sacro Cuore contributed to the funding of this research project and its publication.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/7/23
Y1 - 2021/7/23
N2 - Recent advancements in bidimensional nanoparticles production such as graphene (G) and graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) against SARS-CoV-2 infection. The ability of G and GO to interact with microorganisms provides an opportunity to develop engineered textiles for use in PPE and limit the spread of COVID-19. PPE in current use in high-risk settings for COVID transmission provides only a physical barrier that decreases infection likelihood and does not inactivate the virus. Here, we show that virus pre-incubation with soluble GO inhibits SARS-CoV-2 infection of VERO cells. Furthermore, when G/GO-functionalized polyurethane or cotton was in contact SARS-CoV-2, the infectivity of the fabric was nearly completely inhibited. The findings presented here constitute an important innovative nanomaterial-based strategy to significantly increase PPE efficacy in protection against the SARS-CoV-2 virus that may implement water filtration, air purification, and diagnostics methods.
AB - Recent advancements in bidimensional nanoparticles production such as graphene (G) and graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) against SARS-CoV-2 infection. The ability of G and GO to interact with microorganisms provides an opportunity to develop engineered textiles for use in PPE and limit the spread of COVID-19. PPE in current use in high-risk settings for COVID transmission provides only a physical barrier that decreases infection likelihood and does not inactivate the virus. Here, we show that virus pre-incubation with soluble GO inhibits SARS-CoV-2 infection of VERO cells. Furthermore, when G/GO-functionalized polyurethane or cotton was in contact SARS-CoV-2, the infectivity of the fabric was nearly completely inhibited. The findings presented here constitute an important innovative nanomaterial-based strategy to significantly increase PPE efficacy in protection against the SARS-CoV-2 virus that may implement water filtration, air purification, and diagnostics methods.
KW - Disease
KW - Health sciences
KW - Materials science
KW - Nanostructure
KW - Public health
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U2 - 10.1016/j.isci.2021.102788
DO - 10.1016/j.isci.2021.102788
M3 - Article
AN - SCOPUS:85109430622
SN - 2589-0042
VL - 24
JO - iScience
JF - iScience
IS - 7
M1 - 102788
ER -