TY - JOUR
T1 - Gonadal damage in Hodgkin's disease from cancer chemotherapeutic regimens
AU - Bonadonna, G.
AU - Santoro, A.
AU - Viviani, S.
PY - 1984
Y1 - 1984
N2 - The paper re-emphasizes that intesive prolonged anticancer chemotherapy containing alkylating agents or procarbazine or both produces a high-incidence of gonadal failure, particularly in males. This evidence has been documented mostly in patients with Hodgkin's disease. On the contrary, effective combination regimens, such as ABVD, not including the above mentioned drugs induce a comparatively less and transient germ cell toxicity. In devising chemotherapy for potentially curable neoplastic diseases in young patients efforts should be made to avoid or minimize the potential risk of drug-induced gonadal failure.
AB - The paper re-emphasizes that intesive prolonged anticancer chemotherapy containing alkylating agents or procarbazine or both produces a high-incidence of gonadal failure, particularly in males. This evidence has been documented mostly in patients with Hodgkin's disease. On the contrary, effective combination regimens, such as ABVD, not including the above mentioned drugs induce a comparatively less and transient germ cell toxicity. In devising chemotherapy for potentially curable neoplastic diseases in young patients efforts should be made to avoid or minimize the potential risk of drug-induced gonadal failure.
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U2 - 10.1007/978-3-642-69132-4_16
DO - 10.1007/978-3-642-69132-4_16
M3 - Article
C2 - 6083763
AN - SCOPUS:0021690195
SN - 0003-9446
VL - 55
SP - 140
EP - 145
JO - Archiv fur Toxikologie
JF - Archiv fur Toxikologie
IS - SUPPL. 7
ER -