GM-CSF contributes to prompt healing of ecthyma gangrenosum lesions in kidney transplant recipient

Marilena Gregorini, Michela Castello, Teresa Rampino, Francesca Bosio, Giulia Bedino, Pasquale Esposito, Giovanni Borroni, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review


Background: Ecthyma gangrenosum (EG) is an unusual, potentially fatal cutaneous disease, commonly associated with Pseudomonas aeruginosa septicemia. Case report: We report the case of a 61-year-old man admitted to the Nephrology Department for fever, leukopenia and inguinal and scrotal painful lesions. Physical examination revealed inguinal and scrotal macules, nodules, blisters and ulcers with central necrosis. P. aeruginosa was isolated from an ulcer. EG was diagnosed. Because of the severe leukopenia, granulocyte-macrophage colony-stimulating factor (GM-CSF) was administered until the white blood cell count significantly increased. Based on antibiogram, intravenous ceftazidime and teicoplanin were given for 11 days. Cutaneous manifestations were completely healed in about 2 months. Conclusion: We suggest that the combination of GMCSF with appropriate antibiotics can resolve EG and avoid or minimize the risk of septicemia in immunosuppressed patients.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalJournal of Nephrology
Issue number1
Publication statusPublished - Feb 2012


  • Ecthyma gangrenosum
  • Kidney transplant
  • Leukopenia
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Nephrology


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