Abstract
In addition to CD4 and chemokine receptors glycosyl phosphatidylinositol- anchored proteins (GPI-APs) have been involved in the regulation of the human immunodeficiency virus (HIV) life cycle. In this article we will review the mechanisms underlying the anti-HIV activities regulated by GPI-APs and their ligands. Understanding how GPI-APs finely regulate HIV infection and replication may unravel novel and complementary strategies to combat and control HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 598-604 |
| Number of pages | 7 |
| Journal | Letters in Drug Design and Discovery |
| Volume | 3 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2006 |
Keywords
- GPI (Glycosyl Phosphatidylinositol)
- GPI-AP (Glycosyl Phosphatidylinositol- Anchored Protein)
- HIV (Human Immunodeficiency Virus)
- PTXB (pertussis toxin B-oligomer)
- uPA (urokinase plasminogen activator)
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Molecular Medicine