GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis

Heinz Wiendl; C. G. Bien; P. Bernasconi; B. Fleckenstein; C. E. Elger; J. Dichgans; R. Mantegazza; A. Melms

GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis

Heinz Wiendl, C. G. Bien, P. Bernasconi, B. Fleckenstein, C. E. Elger, J. Dichgans, R. Mantegazza, A. Melms

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.

Original language	English
Pages (from-to)	1511-1514
Number of pages	4
Journal	Neurology
Volume	57
Issue number	8
Publication status	Published - Oct 23 2001

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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abstract = "Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.",

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AU - Wiendl, Heinz

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AU - Bernasconi, P.

AU - Fleckenstein, B.

AU - Elger, C. E.

AU - Dichgans, J.

AU - Mantegazza, R.

AU - Melms, A.

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N2 - Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.

AB - Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.

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ER -

GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis

Abstract

ASJC Scopus subject areas

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