Glucagonoma syndrome and necrolytic migratory erythema

Franco Rongioletti

doi:10.1007/978-1-60761-181-3_16

Glucagonoma syndrome and necrolytic migratory erythema

Franco Rongioletti

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Necrolytic migratory erythema is a cutaneous paraneoplastic manifestation, which is usually associated with a glucagon-secreting pancreatic tumor. Clues to the diagnosis are the anatomic distribution (perioral, acral, and genital), the waxing and waning course, the figurate migratory lesions with advancing scaling-borders, and the distinctive histopathologic pattern with pale, vacuolated keratinocytes in the upper epidermis. Necrolytic migratory erythema heals once the glucagonoma has been surgically removed, but in 50% of these cases metastasis exists at the moment of the diagnosis.

Original language	English
Title of host publication	Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease
Publisher	Springer New York
Pages	121-124
Number of pages	4
ISBN (Print)	9781607611806
DOIs	https://doi.org/10.1007/978-1-60761-181-3_16
Publication status	Published - 2010

Keywords

Glucagon-secreting pancreatic tumor
Glucagonoma syndrome
Necrolytic migratory erythema

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-60761-181-3_16

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abstract = "Necrolytic migratory erythema is a cutaneous paraneoplastic manifestation, which is usually associated with a glucagon-secreting pancreatic tumor. Clues to the diagnosis are the anatomic distribution (perioral, acral, and genital), the waxing and waning course, the figurate migratory lesions with advancing scaling-borders, and the distinctive histopathologic pattern with pale, vacuolated keratinocytes in the upper epidermis. Necrolytic migratory erythema heals once the glucagonoma has been surgically removed, but in 50% of these cases metastasis exists at the moment of the diagnosis.",

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AB - Necrolytic migratory erythema is a cutaneous paraneoplastic manifestation, which is usually associated with a glucagon-secreting pancreatic tumor. Clues to the diagnosis are the anatomic distribution (perioral, acral, and genital), the waxing and waning course, the figurate migratory lesions with advancing scaling-borders, and the distinctive histopathologic pattern with pale, vacuolated keratinocytes in the upper epidermis. Necrolytic migratory erythema heals once the glucagonoma has been surgically removed, but in 50% of these cases metastasis exists at the moment of the diagnosis.

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ER -

Glucagonoma syndrome and necrolytic migratory erythema

Abstract

Keywords

ASJC Scopus subject areas

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