Glucagonoma syndrome and necrolytic migratory erythema

Franco Rongioletti

Research output: Chapter in Book/Report/Conference proceedingChapter


Necrolytic migratory erythema is a cutaneous paraneoplastic manifestation, which is usually associated with a glucagon-secreting pancreatic tumor. Clues to the diagnosis are the anatomic distribution (perioral, acral, and genital), the waxing and waning course, the figurate migratory lesions with advancing scaling-borders, and the distinctive histopathologic pattern with pale, vacuolated keratinocytes in the upper epidermis. Necrolytic migratory erythema heals once the glucagonoma has been surgically removed, but in 50% of these cases metastasis exists at the moment of the diagnosis.

Original languageEnglish
Title of host publicationClinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease
PublisherSpringer New York
Number of pages4
ISBN (Print)9781607611806
Publication statusPublished - 2010


  • Glucagon-secreting pancreatic tumor
  • Glucagonoma syndrome
  • Necrolytic migratory erythema

ASJC Scopus subject areas

  • Medicine(all)


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