Glomerular filtration rate is associated with trabecular bone score in patients with type 2 diabetes mellitus

O. Lamacchia, M. R. Sorrentino, G. Berti, M. Paradiso, A. Corrado, F. P. Cantatore, S. De Cosmo

Research output: Contribution to journalArticlepeer-review


AIMS: The present study aimed to evaluate the trabecular and cortical bone components using Trabecular Bone Score (TBS) and its association with estimated-Glomerular Filtration Rate (e-GFR) in T2DM patients. METHODS: An assessment both of bone mineral density (BMD) and vertebral bone microarchitecture was performed in all patients using TBS iNsight® software version Furthermore, the total population was divided into two groups based on the value of the eGFR (eGFR < o > at 60 ml/min/1.73 m2). RESULTS: TBS value was lower in patients with low e-GFR than that in patients with higher e-GFR (1.246 ± 0.125 vs 1.337 ± 0.115, respectively, p = 0.013 adjusted by gender and age) while there was no difference in total BMD value between two groups. In the multivariate model taking into account several possible confounders, such as age, gender, duration of diabetes, BMI, LDL cholesterol, serum calcium and HbA1c, the correlation between e-GFR and TBS remained significant (p: 0.046). CONCLUSIONS: In individuals with T2DM and reduced kidney function, TBS provides information independent of BMD, age and gender. TBS may be a useful additional tool to predict fracture risk in this unique population.

Original languageEnglish
Pages (from-to)108164
Number of pages1
JournalDiabetes Research and Clinical Practice
Publication statusPublished - Jun 1 2020


  • Diabetes mellitus
  • Kidney disease
  • Skeletal fragility
  • Trabecular bone score

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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