Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions

Rosaria Santangelo, Andrea Silvestrini, Cesare Mancuso

Research output: Contribution to journalReview articlepeer-review


Recent studies have shown the role of gut microbiota in favoring the absorption of herbal products and the transformation of their active principles into metabolites endowed with biological activity. This review focuses on the evidence supporting the changes occurring, after metabolic reactions by specific bacteria that colonize the human gut, to ginseng-derived ginsenosides, green tea-derived catechins, and quercetin, this latter being a flavonoid aglycon bound to sugars and abundant in some vegetables and roots. Furthermore, the results of several studies demonstrating the potential beneficial effects of the active metabolites generated by these biotransformations on ginsenosides, catechins and quercetin will be reported.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalFood and Chemical Toxicology
Publication statusPublished - Jan 2019
Externally publishedYes


  • Animals
  • Bacteria/classification
  • Biotransformation
  • Catechin/metabolism
  • Gastrointestinal Microbiome
  • Ginsenosides/metabolism
  • Humans
  • Intestines/microbiology


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