Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Francesco Forconi; Andrea Rinaldi; Ivo Kwee; Elisa Sozzi; Donatella Raspadori; Paola M V Rancoita; Marta Scandurra; Davide Rossi; Clara Deambrogi; Daniela Capello; Emanuele Zucca; Daniela Marconi; Riccardo Bomben; Valter Gattei; Francesco Lauria; Gianluca Gaidano; Francesco Bertoni

doi:10.1111/j.1365-2141.2008.07373.x

Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Francesco Forconi, Andrea Rinaldi, Ivo Kwee, Elisa Sozzi, Donatella Raspadori, Paola M V Rancoita, Marta Scandurra, Davide Rossi, Clara Deambrogi, Daniela Capello, Emanuele Zucca, Daniela Marconi, Riccardo Bomben, Valter Gattei, Francesco Lauria, Gianluca Gaidano, Francesco Bertoni

Research output: Contribution to journal › Article › peer-review

Abstract

Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P <0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

Original language	English
Pages (from-to)	532-536
Number of pages	5
Journal	British Journal of Haematology
Volume	143
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07373.x
Publication status	Published - Nov 2008

Keywords

17p13 deletion
250K Affymetrix
Chronic lymphocytic leukaemia
Genome-wide DNA profile
Single nucleotide polymporphysms
TP53

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2008.07373.x

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Forconi, F., Rinaldi, A., Kwee, I., Sozzi, E., Raspadori, D., Rancoita, P. M. V., Scandurra, M., Rossi, D., Deambrogi, C., Capello, D., Zucca, E., Marconi, D., Bomben, R., Gattei, V., Lauria, F., Gaidano, G., & Bertoni, F. (2008). Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. British Journal of Haematology, 143(4), 532-536. https://doi.org/10.1111/j.1365-2141.2008.07373.x

Forconi, F, Rinaldi, A, Kwee, I, Sozzi, E, Raspadori, D, Rancoita, PMV, Scandurra, M, Rossi, D, Deambrogi, C, Capello, D, Zucca, E, Marconi, D, Bomben, R , Gattei, V, Lauria, F, Gaidano, G & Bertoni, F 2008, 'Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion', British Journal of Haematology, vol. 143, no. 4, pp. 532-536. https://doi.org/10.1111/j.1365-2141.2008.07373.x

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abstract = "Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P <0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.",

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AU - Forconi, Francesco

AU - Rinaldi, Andrea

AU - Kwee, Ivo

AU - Sozzi, Elisa

AU - Raspadori, Donatella

AU - Rancoita, Paola M V

AU - Scandurra, Marta

AU - Rossi, Davide

AU - Deambrogi, Clara

AU - Capello, Daniela

AU - Zucca, Emanuele

AU - Marconi, Daniela

AU - Bomben, Riccardo

AU - Gattei, Valter

AU - Lauria, Francesco

AU - Gaidano, Gianluca

AU - Bertoni, Francesco

PY - 2008/11

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N2 - Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P <0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

AB - Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P <0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

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KW - Single nucleotide polymporphysms

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Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Abstract

Keywords

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