Genetica della emicrania con e senza aura: Analisi di linkage e studi di associazione

M. Mochi; M. L. Valentino; L. Monari; S. Cevoli; P. Cortelli; G. Pierangeli; S. Soriani; P. Montagna

Genetica della emicrania con e senza aura: Analisi di linkage e studi di associazione

Translated title of the contribution: Genetics of migraine with and without aura: Linkage analysis and association studies

M. Mochi, M. L. Valentino, L. Monari, S. Cevoli, P. Cortelli, G. Pierangeli, S. Soriani, P. Montagna

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We performed genetic studies, both linkage and association, to localize the gene/genes responsible for the commonest form of migraine with and without aura. The linkage analysis prompted us to exclude several candidate genes, and the surrounding chromosomal regions, as sites of migraine loci: 5HT1D (1p36), 5HT1B (6q13), 5HT2A (13q14-q21), 5HT Trans and CACNL1B (17q11-q22), CACNL1A4 (19q13), SCNA1,2,3,6 (2q24), CACNL1A1,KCNA1, KC-NA5,KCNA6 (12p13). Association studies were performed between migraine and polymorphic markers within dopamine related genes: dopamine D2 and D3 receptor, monoamino-oxidase A and cathecol-omethyltransferase. We found no statistical difference in the allele frequencies between migraine and control sample.

Translated title of the contribution	Genetics of migraine with and without aura: Linkage analysis and association studies
Original language	Italian
Pages (from-to)	123-128
Number of pages	6
Journal	Confinia Cephalalgica
Volume	9
Issue number	3
Publication status	Published - 2000

ASJC Scopus subject areas

Clinical Neurology

Cite this

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title = "Genetica della emicrania con e senza aura: Analisi di linkage e studi di associazione",

abstract = "We performed genetic studies, both linkage and association, to localize the gene/genes responsible for the commonest form of migraine with and without aura. The linkage analysis prompted us to exclude several candidate genes, and the surrounding chromosomal regions, as sites of migraine loci: 5HT1D (1p36), 5HT1B (6q13), 5HT2A (13q14-q21), 5HT Trans and CACNL1B (17q11-q22), CACNL1A4 (19q13), SCNA1,2,3,6 (2q24), CACNL1A1,KCNA1, KC-NA5,KCNA6 (12p13). Association studies were performed between migraine and polymorphic markers within dopamine related genes: dopamine D2 and D3 receptor, monoamino-oxidase A and cathecol-omethyltransferase. We found no statistical difference in the allele frequencies between migraine and control sample.",

keywords = "Association, Linkage, Migraine",

author = "M. Mochi and Valentino, {M. L.} and L. Monari and S. Cevoli and P. Cortelli and G. Pierangeli and S. Soriani and P. Montagna",

year = "2000",

language = "Italian",

volume = "9",

pages = "123--128",

journal = "Confinia Cephalalgica",

issn = "1122-0279",

publisher = "Fondazione CIRNA",

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TY - JOUR

T1 - Genetica della emicrania con e senza aura

T2 - Analisi di linkage e studi di associazione

AU - Mochi, M.

AU - Valentino, M. L.

AU - Monari, L.

AU - Cevoli, S.

AU - Cortelli, P.

AU - Pierangeli, G.

AU - Soriani, S.

AU - Montagna, P.

PY - 2000

Y1 - 2000

N2 - We performed genetic studies, both linkage and association, to localize the gene/genes responsible for the commonest form of migraine with and without aura. The linkage analysis prompted us to exclude several candidate genes, and the surrounding chromosomal regions, as sites of migraine loci: 5HT1D (1p36), 5HT1B (6q13), 5HT2A (13q14-q21), 5HT Trans and CACNL1B (17q11-q22), CACNL1A4 (19q13), SCNA1,2,3,6 (2q24), CACNL1A1,KCNA1, KC-NA5,KCNA6 (12p13). Association studies were performed between migraine and polymorphic markers within dopamine related genes: dopamine D2 and D3 receptor, monoamino-oxidase A and cathecol-omethyltransferase. We found no statistical difference in the allele frequencies between migraine and control sample.

AB - We performed genetic studies, both linkage and association, to localize the gene/genes responsible for the commonest form of migraine with and without aura. The linkage analysis prompted us to exclude several candidate genes, and the surrounding chromosomal regions, as sites of migraine loci: 5HT1D (1p36), 5HT1B (6q13), 5HT2A (13q14-q21), 5HT Trans and CACNL1B (17q11-q22), CACNL1A4 (19q13), SCNA1,2,3,6 (2q24), CACNL1A1,KCNA1, KC-NA5,KCNA6 (12p13). Association studies were performed between migraine and polymorphic markers within dopamine related genes: dopamine D2 and D3 receptor, monoamino-oxidase A and cathecol-omethyltransferase. We found no statistical difference in the allele frequencies between migraine and control sample.

KW - Association

KW - Linkage

KW - Migraine

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M3 - Articolo

AN - SCOPUS:0034515455

SN - 1122-0279

VL - 9

SP - 123

EP - 128

JO - Confinia Cephalalgica

JF - Confinia Cephalalgica

IS - 3

ER -

Genetica della emicrania con e senza aura: Analisi di linkage e studi di associazione

Abstract

ASJC Scopus subject areas

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