We performed genetic studies, both linkage and association, to localize the gene/genes responsible for the commonest form of migraine with and without aura. The linkage analysis prompted us to exclude several candidate genes, and the surrounding chromosomal regions, as sites of migraine loci: 5HT1D (1p36), 5HT1B (6q13), 5HT2A (13q14-q21), 5HT Trans and CACNL1B (17q11-q22), CACNL1A4 (19q13), SCNA1,2,3,6 (2q24), CACNL1A1,KCNA1, KC-NA5,KCNA6 (12p13). Association studies were performed between migraine and polymorphic markers within dopamine related genes: dopamine D2 and D3 receptor, monoamino-oxidase A and cathecol-omethyltransferase. We found no statistical difference in the allele frequencies between migraine and control sample.
|Translated title of the contribution||Genetics of migraine with and without aura: Linkage analysis and association studies|
|Number of pages||6|
|Publication status||Published - 2000|
ASJC Scopus subject areas
- Clinical Neurology