TY - JOUR
T1 - Genetic instability and increased mutational load
T2 - Which diagnostic tool best direct patients with cancer to immunotherapy?
AU - Palmieri, Giuseppe
AU - Colombino, Maria
AU - Cossu, Antonio
AU - Marchetti, Antonio
AU - Botti, Gerardo
AU - Ascierto, Paolo A.
PY - 2017/1/21
Y1 - 2017/1/21
N2 - The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.
AB - The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.
UR - http://www.scopus.com/inward/record.url?scp=85009999839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009999839&partnerID=8YFLogxK
U2 - 10.1186/s12967-017-1119-6
DO - 10.1186/s12967-017-1119-6
M3 - Comment/debate
AN - SCOPUS:85009999839
SN - 1479-5876
VL - 15
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
IS - 1
M1 - 17
ER -