TY - JOUR
T1 - Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice
AU - Gariboldi, Manuela
AU - Spinola, Monica
AU - Milani, Silvano
AU - Pignatiello, Carmen
AU - Kadota, Koji
AU - Bono, Hidemasa
AU - Hayashizaki, Yoshihide
AU - Dragani, Tommaso A.
AU - Okazaki, Yasushi
PY - 2003/11
Y1 - 2003/11
N2 - Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.
AB - Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.
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U2 - 10.1093/carcin/bgg133
DO - 10.1093/carcin/bgg133
M3 - Article
C2 - 12919955
AN - SCOPUS:0242392008
SN - 0143-3334
VL - 24
SP - 1819
EP - 1826
JO - Carcinogenesis
JF - Carcinogenesis
IS - 11
ER -