TY - JOUR
T1 - Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori
T2 - Scratch and win
AU - Franco, Monica
AU - Rugge, Massimo
AU - D'Andrea, Emma
AU - Mescoli, Claudia
AU - Menin, Chiara
AU - Farinati, Fabio
PY - 2005/1
Y1 - 2005/1
N2 - Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with Helicobacter pylori infection and, in the great majority of patients, regresses after eradication. H. pylori-negative MALT lymphoma occurs in a small minority of cases in which treatment is based on surgery or chemoradiotherapy. In the search for H. pylori based on histology and the C 13 urea breath test, this report describes a case with a series of false-negative results, thus confirming the possibility of a lower detectability of H. pylori in patients with MALT gastric lymphoma and supporting the use of additional tests in evaluating such pathology, including polymerase chain reaction. Additionally, treatment with CD20 monoclonal antibody (rituximab) is suggested as an alternative to surgery or treatment with chemotherapy or radiotherapy in patients with truly H. pylori-negative gastric MALT lymphoma.
AB - Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with Helicobacter pylori infection and, in the great majority of patients, regresses after eradication. H. pylori-negative MALT lymphoma occurs in a small minority of cases in which treatment is based on surgery or chemoradiotherapy. In the search for H. pylori based on histology and the C 13 urea breath test, this report describes a case with a series of false-negative results, thus confirming the possibility of a lower detectability of H. pylori in patients with MALT gastric lymphoma and supporting the use of additional tests in evaluating such pathology, including polymerase chain reaction. Additionally, treatment with CD20 monoclonal antibody (rituximab) is suggested as an alternative to surgery or treatment with chemotherapy or radiotherapy in patients with truly H. pylori-negative gastric MALT lymphoma.
KW - CD20 monoclonal antibody
KW - Helicobacter pylori
KW - MALT lymphoma
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U2 - 10.1080/00365520410009438
DO - 10.1080/00365520410009438
M3 - Article
C2 - 15841725
AN - SCOPUS:12444293700
SN - 0036-5521
VL - 40
SP - 115
EP - 119
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 1
ER -