Galectin-10, eosinophils, and celiac disease

Valli De Re, Maria Paola Simula, Renato Cannizzaro, Alessandro Pavan, Mari Angela De Zorzi, Giuseppe Toffoli, Vincenzo Canzonieri

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Celiac disease (CD) is a chronic intestinal disease caused by intolerance to dietary wheat gluten in genetically susceptible individuals. There are a number of important open questions that impede the full explanation of the pathogenesis of this disease. We analyzed protein expression pattern in gut biopsies of CD subjects. Patients were selected and grouped according to histological inflammatory degree. Groups consisted of nine individuals with CD: three patients had a Marsh 0, three a Marsh I-II, and three a Marsh III. All CD patients showed a human leukocyte antigen DQ28 variant. Controls were three individuals with an excluded CD diagnosis. For the first time, galectin-10 expression was found related to the histological grade (P = 0.0092) and with the number of eosinophils in the lesion (P = 0.0040). Results suggest galectin-10 is a novel marker for evaluating CD tissue damage and eosinophils as a possible target for therapeutic approaches. Moreover, our data provide insights into alterations associated with CD tissue damage and pathogenesis.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages8
Publication statusPublished - Sept 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • 2D-DIGE
  • Celiac disease
  • Charcot Leyden
  • Eosinophil
  • Galectin-10

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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