TY - GEN
T1 - Galectin-10, eosinophils, and celiac disease
AU - De Re, Valli
AU - Simula, Maria Paola
AU - Cannizzaro, Renato
AU - Pavan, Alessandro
AU - De Zorzi, Mari Angela
AU - Toffoli, Giuseppe
AU - Canzonieri, Vincenzo
PY - 2009/9
Y1 - 2009/9
N2 - Celiac disease (CD) is a chronic intestinal disease caused by intolerance to dietary wheat gluten in genetically susceptible individuals. There are a number of important open questions that impede the full explanation of the pathogenesis of this disease. We analyzed protein expression pattern in gut biopsies of CD subjects. Patients were selected and grouped according to histological inflammatory degree. Groups consisted of nine individuals with CD: three patients had a Marsh 0, three a Marsh I-II, and three a Marsh III. All CD patients showed a human leukocyte antigen DQ28 variant. Controls were three individuals with an excluded CD diagnosis. For the first time, galectin-10 expression was found related to the histological grade (P = 0.0092) and with the number of eosinophils in the lesion (P = 0.0040). Results suggest galectin-10 is a novel marker for evaluating CD tissue damage and eosinophils as a possible target for therapeutic approaches. Moreover, our data provide insights into alterations associated with CD tissue damage and pathogenesis.
AB - Celiac disease (CD) is a chronic intestinal disease caused by intolerance to dietary wheat gluten in genetically susceptible individuals. There are a number of important open questions that impede the full explanation of the pathogenesis of this disease. We analyzed protein expression pattern in gut biopsies of CD subjects. Patients were selected and grouped according to histological inflammatory degree. Groups consisted of nine individuals with CD: three patients had a Marsh 0, three a Marsh I-II, and three a Marsh III. All CD patients showed a human leukocyte antigen DQ28 variant. Controls were three individuals with an excluded CD diagnosis. For the first time, galectin-10 expression was found related to the histological grade (P = 0.0092) and with the number of eosinophils in the lesion (P = 0.0040). Results suggest galectin-10 is a novel marker for evaluating CD tissue damage and eosinophils as a possible target for therapeutic approaches. Moreover, our data provide insights into alterations associated with CD tissue damage and pathogenesis.
KW - 2D-DIGE
KW - Celiac disease
KW - Charcot Leyden
KW - Eosinophil
KW - Galectin-10
UR - http://www.scopus.com/inward/record.url?scp=69949123793&partnerID=8YFLogxK
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U2 - 10.1111/j.1749-6632.2009.04627.x
DO - 10.1111/j.1749-6632.2009.04627.x
M3 - Conference contribution
C2 - 19758173
AN - SCOPUS:69949123793
SN - 9781573317627
VL - 1173
T3 - Annals of the New York Academy of Sciences
SP - 357
EP - 364
BT - Annals of the New York Academy of Sciences
ER -