Fundus autofluorescence patterns in best vitelliform macular dystrophy

Maurizio Battaglia Parodi, Pierluigi Iacono, Claudio Campa, Claudia Del Turco, Francesco Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To provide a systematic classification of fundus autofluorescence (FAF) patterns in patients affected by Best vitelliform macular dystrophy.

Design: Cross-sectional prospective study.

Methods: Patients affected by Best vitelliformmacular dystrophy at different stages of the disease were prospectively enrolled from January 2012 to July 2013. Eighty eyes of 40 patients were included in the study. All patients underwent a complete ophthalmologic examination, including genetic characterization, short-wavelength FAF, and near-infrared FAF. Main outcome measures were the recognition of the FAF patterns in the different stages and the identification of a relationship between FAF patterns and best-corrected visual acuity (BCVA).

Results: Six FAF patterns for both short-wavelength and near-infrared FAF were identified, including normal, hyper-autofluorescent, hypo-autofluorescent, patchy, multifocal, and spoke-like patterns.ApplyingGasss classification for defining consecutive stages of Best vitelliform macular dystrophy (namely vitelliform, pseudohypopyon, vitelliruptive, atrophic, and cicatricial) identified no pattern as stage-specific. Patchy patterns had the highest prevalence. A statistically significant difference (Kruskal- Wallis ANOVA) was found among hyperautofluorescent, patchy, and hypo-autofluorescent patterns, both in short-wavelength (P = .001) and nearinfrared FAF (P = .001). Hyper-autofluorescent and hypo-autofluorescent patterns were associated with better and worse BCVA, respectively.

Conclusion: Six main patterns on both shortwavelength and near-infrared FAF were identified in Best vitelliform macular dystrophy.NoFAFpattern can be considered stage-specific. Although a difference in the BCVA among the FAF patterns was registered, only a longitudinal study designed to evaluate the clinical and FAF modifications over the follow-up will help clarify the prognostic implications of each FAF pattern.

Original languageEnglish
Pages (from-to)1086-1092
Number of pages7
JournalAmerican Journal of Ophthalmology
Issue number5
Publication statusPublished - Nov 1 2014

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)


Dive into the research topics of 'Fundus autofluorescence patterns in best vitelliform macular dystrophy'. Together they form a unique fingerprint.

Cite this