TY - JOUR
T1 - Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro
AU - Esposito, Claudio
AU - Masotti, Andrea
AU - Del Grosso, Nicoletta
AU - Malizia, Daniela
AU - Bianco, Armandodoriano
AU - Bonadies, Francesco
AU - Napolitano, Raffaella
AU - Ortaggi, Giancarlo
AU - Mossa, Giuseppe
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes.
AB - Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes.
KW - Cationic liposomes
KW - Gene therapy
KW - Glioma
KW - pH-dependent lipids
KW - Transfection
UR - http://www.scopus.com/inward/record.url?scp=0042861535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042861535&partnerID=8YFLogxK
U2 - 10.1016/S1631-0748(03)00085-7
DO - 10.1016/S1631-0748(03)00085-7
M3 - Article
AN - SCOPUS:0042861535
SN - 1631-0748
VL - 6
SP - 617
EP - 622
JO - Comptes Rendus Chimie
JF - Comptes Rendus Chimie
IS - 5-6
ER -