Abstract
Basophil releasability was studied in 24 cord blood samples from normal-term deliveries. The histamine content in cord blood basophils was similar to that of adult blood basophils. The response to IgE-independent degranulating stimuli such as calcium ionophore A23187 and zymosan-activated human serum was overlapping with that of normal adults. Conversely, a reduced releasability was observed after challenge with anti-IgE, even after sensitization with an IgE-rich serum. The IgE-dependent degranulation seems to be hampered by the low concentrations of circulating and cell-bound IgE antibodies. The number of IgE molecules bound to the specific receptors in cord blood basophils is significantly lower than in adult blood basophils.
| Original language | English |
|---|---|
| Pages (from-to) | 276-283 |
| Number of pages | 8 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 81 |
| Issue number | 3 |
| Publication status | Published - 1986 |
ASJC Scopus subject areas
- Immunology and Allergy