Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

G. C. Minetti; C. Colussi; R. Adami; C. Serra; C. Mozzetta; V. Parente; S. Fortuni; S. Straino; M. Sampaolesi; M. Di Padova; B. Illi; P. Gallinari; C. Steinkühler; M. C. Capogrossi; V. Sartorelli; R. Bottinelli; C. Gaetano; P. L. Puri

doi:10.1038/nm1479

Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

G. C. Minetti, C. Colussi, R. Adami, C. Serra, C. Mozzetta, V. Parente, S. Fortuni, S. Straino, M. Sampaolesi, M. Di Padova, B. Illi, P. Gallinari, C. Steinkühler, M. C. Capogrossi, V. Sartorelli, R. Bottinelli, C. Gaetano, P. L. Puri

Research output: Contribution to journal › Article › peer-review

Abstract

Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles. We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and α-sarcoglycan (α-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies.

Original language	English
Pages (from-to)	1147-1150
Number of pages	4
Journal	Nature Medicine
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nm1479
Publication status	Published - Oct 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Minetti, G. C., Colussi, C., Adami, R., Serra, C., Mozzetta, C., Parente, V., Fortuni, S., Straino, S., Sampaolesi, M., Di Padova, M., Illi, B., Gallinari, P., Steinkühler, C., Capogrossi, M. C., Sartorelli, V., Bottinelli, R., Gaetano, C., & Puri, P. L. (2006). Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nature Medicine, 12(10), 1147-1150. https://doi.org/10.1038/nm1479

Minetti, GC, Colussi, C, Adami, R, Serra, C, Mozzetta, C, Parente, V, Fortuni, S, Straino, S, Sampaolesi, M, Di Padova, M, Illi, B, Gallinari, P, Steinkühler, C, Capogrossi, MC, Sartorelli, V, Bottinelli, R, Gaetano, C & Puri, PL 2006, 'Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors', Nature Medicine, vol. 12, no. 10, pp. 1147-1150. https://doi.org/10.1038/nm1479

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abstract = "Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles. We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and α-sarcoglycan (α-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies.",

author = "Minetti, {G. C.} and C. Colussi and R. Adami and C. Serra and C. Mozzetta and V. Parente and S. Fortuni and S. Straino and M. Sampaolesi and {Di Padova}, M. and B. Illi and P. Gallinari and C. Steink{\"u}hler and Capogrossi, {M. C.} and V. Sartorelli and R. Bottinelli and C. Gaetano and Puri, {P. L.}",

year = "2006",

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AU - Minetti, G. C.

AU - Colussi, C.

AU - Adami, R.

AU - Serra, C.

AU - Mozzetta, C.

AU - Parente, V.

AU - Fortuni, S.

AU - Straino, S.

AU - Sampaolesi, M.

AU - Di Padova, M.

AU - Illi, B.

AU - Gallinari, P.

AU - Steinkühler, C.

AU - Capogrossi, M. C.

AU - Sartorelli, V.

AU - Bottinelli, R.

AU - Gaetano, C.

AU - Puri, P. L.

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AB - Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles. We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and α-sarcoglycan (α-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies.

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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

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