Frequency of Non-motor Symptoms in Parkinson's Patients With Motor Fluctuations

Mariana Fernandes, Mariangela Pierantozzi, Alessandro Stefani, Carlo Cattaneo, Erminio A. Bonizzoni, Rocco Cerroni, Nicola Biagio Mercuri, Claudio Liguori

Research output: Contribution to journalArticlepeer-review


Background: Non-motor symptoms (NMS), including neuropsychiatric, sleep, autonomic, and sensory domains, are an integral aspect of the clinical presentation of Parkinson disease (PD) and affect neurocognitive functioning as well as patients' and caregivers' well-being. Objective: To describe the occurrence of NMS in PD patients with motor fluctuations in real-life condition. Methods: The present study is a secondary analysis of a previous multinational, multicenter, retrospective-prospective cohort observational study (SYNAPSES). Patients with PD diagnosis and motor fluctuations aged ≥18 years were included. Data collected at the baseline visit were used for this study, and descriptive analyzes were conducted to describe the distribution of NMS in motor-fluctuating PD patients distributed according to different clinical characteristics. Results: Of the 1,610 patients enrolled, 1,589 were included for the analysis (978 males and 611 females), with a mean age of 68.4 (SD = 9.6). Most patients had at least one NMS (88.5%). Sleep problems and psychiatric symptoms were the most prevalent NMS in motor fluctuating PD patients in all H and Y stages. Psychiatric disorders were more frequent in older patients and in patients with a larger number of years of PD diagnosis, while sleep problems were more preeminent in younger patients and with inferior disease duration. Conclusions: The present findings further support the high prevalence of NMS in PD patients with motor fluctuations, thus reinforcing the need for assessing them for diagnostic accuracy and for delivering holistic care.

Original languageEnglish
Article number678373
JournalFrontiers in Neurology
Publication statusPublished - Jun 29 2021


  • fatigue
  • idiopathic Parkinson disease
  • motor fluctuations
  • psychiatric disorder
  • real-word data
  • sleep

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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