Food allergy as defined by component resolved diagnosis

Cristoforo Incorvaia, Andrea Rapetti, Maria Aliani, Corrado Castagneto, Nicoletta Corso, Massimo Landi, Daniele Lietti, Nicolangelo Murante, Lionello Muratore, Marina Russello, Elena Varin, Eleni Makrì, Nicola Fuiano, Enrico Scala

Research output: Contribution to journalArticlepeer-review


The diagnosis of food allergy, as assessed by skin tests or in vitro tests with allergen extracts, has insufficient diagnostic performance and needs to be confirmed by food challenges. However, the availability of molecular allergens (recombinant or highly purified) for laboratory methods has profoundly changed the diagnostic approach to food allergy. In fact, the allergy diagnosis conducted at the molecular level, which is defined internationally as component resolved diagnosis (CRD), allows to characterize more precisely the sensitization profile of the individual patient, distinguishing the sensitizations to allergens that are strongly associated with a given source (genuine sensitizers) from those to molecules that are common to many sources (panallergens) or cross-react with other components from the same family or from other families. This review provides an update on the allergen molecules from foods, including plant foods and animal foods, and on the techniques to detect them, by means of a single reagent (singleplex) or an array of molecules tested at the same time (multiplex). Such testing offers detailed information on the sensitization profile of patients and enables the physician to suitably manage their allergy. Moreover, identifying the real causative allergens will be crucial when allergen immunotherapy for food allergy will be introduced in the near future. We also address patents concerning food allergens in this review.

Original languageEnglish
Pages (from-to)59-73
Number of pages15
JournalRecent Patents on Inflammation and Allergy Drug Discovery
Issue number1
Publication statusPublished - 2014


  • Allergen immunotherapy
  • Component resolved diagnosis
  • Cross-reacting allergens
  • Diagnostic tests
  • Food allergy
  • Genuine sensitizers
  • Management

ASJC Scopus subject areas

  • Drug Discovery
  • Immunology and Allergy


Dive into the research topics of 'Food allergy as defined by component resolved diagnosis'. Together they form a unique fingerprint.

Cite this