First impressions about Adherus, a new dural sealant

Cesare Zoia, Daniele Bongetta, Francesco Lombardi, Viola Marta Custodi, Raffaelino Pugliese, Paolo Gaetani

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of the study is to report our first impressions about Adherus, a novel dural sealant, used in neurosurgical endoscopic transnasal procedures. Methods: We retrospectively reviewed the clinical and surgical records of the first 11 patients with intraoperative high-flow cerebrospinal fluid leak treated with the aid of Adherus at our center between February and October 2014. The healing at the level of the dural plasty was monitored and evaluated radiologically and with regular endoscopic inspections. Results: With a median follow-up of 210 days, no postoperative CSF leak or surgical site infections were found in any of the cases. Conclusions: Based on our preliminary experience, this new dural sealant seems to provide an effective aid in dural plasty during endoscopic transphenoidal procedures.

Original languageEnglish
Pages (from-to)e372-e375
JournalJournal of Applied Biomaterials and Functional Materials
Issue number4
Publication statusPublished - 2015


  • Dural sealant
  • Polytheyleneimine
  • Postoperative cerebrospinal fluid leaks
  • Transphenoidal endoscopic surgery

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials


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