Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma

M. E. Gore; C. Szczylik; C. Porta; S. Bracarda; G. A. Bjarnason; S. Oudard; S. H. Lee; J. Haanen; D. Castellano; E. Vrdoljak; P. Schöffski; P. Mainwaring; R. E. Hawkins; L. Crinò; T. M. Kim; G. Carteni; W. E E Eberhardt; K. Zhang; K. Fly; E. Matczak; M. J. Lechuga; S. Hariharan; R. Bukowski

doi:10.1038/bjc.2015.199

Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma

M. E. Gore, C. Szczylik, C. Porta, S. Bracarda, G. A. Bjarnason, S. Oudard, S. H. Lee, J. Haanen, D. Castellano, E. Vrdoljak, P. Schöffski, P. Mainwaring, R. E. Hawkins, L. Crinò, T. M. Kim, G. Carteni, W. E E Eberhardt, K. Zhang, K. Fly, E. MatczakM. J. Lechuga, S. Hariharan, R. Bukowski

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.Methods:We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.Results:Seven SNPs showed associations on multivariable analysis (P

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	British Journal of Cancer
Volume	113
Issue number	1
DOIs	https://doi.org/10.1038/bjc.2015.199
Publication status	Published - Jun 30 2015

Keywords

expanded-access trial
prognosis
Renal cell carcinoma
sunitinib
tyrosine kinase inhibitor

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/bjc.2015.199

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Gore, M. E., Szczylik, C., Porta, C., Bracarda, S., Bjarnason, G. A., Oudard, S., Lee, S. H., Haanen, J., Castellano, D., Vrdoljak, E., Schöffski, P., Mainwaring, P., Hawkins, R. E., Crinò, L., Kim, T. M., Carteni, G., Eberhardt, W. E. E., Zhang, K., Fly, K., ... Bukowski, R. (2015). Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma. British Journal of Cancer, 113(1), 12-19. https://doi.org/10.1038/bjc.2015.199

Gore, ME, Szczylik, C, Porta, C, Bracarda, S, Bjarnason, GA, Oudard, S, Lee, SH, Haanen, J, Castellano, D, Vrdoljak, E, Schöffski, P, Mainwaring, P, Hawkins, RE, Crinò, L, Kim, TM, Carteni, G, Eberhardt, WEE, Zhang, K, Fly, K, Matczak, E, Lechuga, MJ, Hariharan, S & Bukowski, R 2015, 'Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma', British Journal of Cancer, vol. 113, no. 1, pp. 12-19. https://doi.org/10.1038/bjc.2015.199

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abstract = "Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.Methods:We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.Results:Seven SNPs showed associations on multivariable analysis (P",

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author = "Gore, {M. E.} and C. Szczylik and C. Porta and S. Bracarda and Bjarnason, {G. A.} and S. Oudard and Lee, {S. H.} and J. Haanen and D. Castellano and E. Vrdoljak and P. Sch{\"o}ffski and P. Mainwaring and Hawkins, {R. E.} and L. Crin{\`o} and Kim, {T. M.} and G. Carteni and Eberhardt, {W. E E} and K. Zhang and K. Fly and E. Matczak and Lechuga, {M. J.} and S. Hariharan and R. Bukowski",

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doi = "10.1038/bjc.2015.199",

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AU - Gore, M. E.

AU - Szczylik, C.

AU - Porta, C.

AU - Bracarda, S.

AU - Bjarnason, G. A.

AU - Oudard, S.

AU - Lee, S. H.

AU - Haanen, J.

AU - Castellano, D.

AU - Vrdoljak, E.

AU - Schöffski, P.

AU - Mainwaring, P.

AU - Hawkins, R. E.

AU - Crinò, L.

AU - Kim, T. M.

AU - Carteni, G.

AU - Eberhardt, W. E E

AU - Zhang, K.

AU - Fly, K.

AU - Matczak, E.

AU - Lechuga, M. J.

AU - Hariharan, S.

AU - Bukowski, R.

PY - 2015/6/30

Y1 - 2015/6/30

N2 - Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.Methods:We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.Results:Seven SNPs showed associations on multivariable analysis (P

AB - Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.Methods:We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determined if SNPs were associated with PSA at diagnosis.Results:Seven SNPs showed associations on multivariable analysis (P

KW - expanded-access trial

KW - prognosis

KW - Renal cell carcinoma

KW - sunitinib

KW - tyrosine kinase inhibitor

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Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma

Abstract

Keywords

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