Fibrinolytic response in normal subjects to venous occlusion and DDAVP infusion

M. Cugno; L. Uziel; I. Fabrizi; B. Bottasso; F. Maggiolini; A. Agostoni

doi:10.1016/0049-3848(89)90270-3

Fibrinolytic response in normal subjects to venous occlusion and DDAVP infusion

M. Cugno, L. Uziel, I. Fabrizi, B. Bottasso, F. Maggiolini, A. Agostoni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

A set of fibrinolytic parameters was measured in 40 healthy subjects before and after a venous occlusion (VO) test lasting 10 min. After VO, plasma levels of tissue-type plasminogen activator (t-PA) antigen increased in all subjects, t-PA activity increased only in 25 subjects who were considered responders and remained unchanged in 15 (non-responders). High levels of plasminogen activator inhibitor (PAI) in the non-responder group explain this discrepancy. The non-responders had basal levels of PAI activity and t-PA antigen higher than responders (p

Original language	English
Pages (from-to)	625-634
Number of pages	10
Journal	Thrombosis Research
Volume	56
Issue number	5
DOIs	https://doi.org/10.1016/0049-3848(89)90270-3
Publication status	Published - Dec 1 1989

Keywords

Desmopressin
plasminogen activator inhibitor
tissue-type plasminogen activator
Venous occlusion

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

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10.1016/0049-3848(89)90270-3

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abstract = "A set of fibrinolytic parameters was measured in 40 healthy subjects before and after a venous occlusion (VO) test lasting 10 min. After VO, plasma levels of tissue-type plasminogen activator (t-PA) antigen increased in all subjects, t-PA activity increased only in 25 subjects who were considered responders and remained unchanged in 15 (non-responders). High levels of plasminogen activator inhibitor (PAI) in the non-responder group explain this discrepancy. The non-responders had basal levels of PAI activity and t-PA antigen higher than responders (p",

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AU - Cugno, M.

AU - Uziel, L.

AU - Fabrizi, I.

AU - Bottasso, B.

AU - Maggiolini, F.

AU - Agostoni, A.

PY - 1989/12/1

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AB - A set of fibrinolytic parameters was measured in 40 healthy subjects before and after a venous occlusion (VO) test lasting 10 min. After VO, plasma levels of tissue-type plasminogen activator (t-PA) antigen increased in all subjects, t-PA activity increased only in 25 subjects who were considered responders and remained unchanged in 15 (non-responders). High levels of plasminogen activator inhibitor (PAI) in the non-responder group explain this discrepancy. The non-responders had basal levels of PAI activity and t-PA antigen higher than responders (p

KW - Desmopressin

KW - plasminogen activator inhibitor

KW - tissue-type plasminogen activator

KW - Venous occlusion

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Fibrinolytic response in normal subjects to venous occlusion and DDAVP infusion

Abstract

Keywords

ASJC Scopus subject areas

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