TY - JOUR
T1 - FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
AU - Spinola, Monica
AU - Leoni, Vera Piera
AU - Tanuma, Jun Ichi
AU - Pettinicchio, Angela
AU - Frattini, Milo
AU - Signoroni, Stefano
AU - Agresti, Roberto
AU - Giovanazzi, Riccardo
AU - Pilotti, Silvana
AU - Bertario, Lucio
AU - Ravagnani, Fernando
AU - Dragani, Tommaso A.
PY - 2005/8
Y1 - 2005/8
N2 - A functional Gly388Arg variation in the FGFR4 gene has been reported to be associated with breast and colorectal cancer prognostic parameters. To further examine the functional role of this genetic polymorphism at the population level, we assessed the presence of the Arg388 allele in 142 breast carcinoma patients, 179 colorectal carcinoma patients and 220 general population controls with respect to an association with cancer prognosis and/or risk. No significant association with cancer risk, survival or any other prognostic parameters was observed in either breast or colorectal cancer. A pooled analysis of the present and published data on nodal status by FGFR4 genotypes revealed no association in either breast cancer [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.7-1.4; 702 subjects] or colorectal cancer (OR, 1.4; 95% CI, 0.6-3.4; 260 cases). Thus, the FGFR4 polymorphism may not be relevant in predicting nodal involvement of breast cancer or colon cancer patients.
AB - A functional Gly388Arg variation in the FGFR4 gene has been reported to be associated with breast and colorectal cancer prognostic parameters. To further examine the functional role of this genetic polymorphism at the population level, we assessed the presence of the Arg388 allele in 142 breast carcinoma patients, 179 colorectal carcinoma patients and 220 general population controls with respect to an association with cancer prognosis and/or risk. No significant association with cancer risk, survival or any other prognostic parameters was observed in either breast or colorectal cancer. A pooled analysis of the present and published data on nodal status by FGFR4 genotypes revealed no association in either breast cancer [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.7-1.4; 702 subjects] or colorectal cancer (OR, 1.4; 95% CI, 0.6-3.4; 260 cases). Thus, the FGFR4 polymorphism may not be relevant in predicting nodal involvement of breast cancer or colon cancer patients.
KW - Fibroblast growth factor receptor 4
KW - Genetic polymorphisms
KW - Genetic predisposition
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M3 - Article
C2 - 16012724
AN - SCOPUS:24744451851
SN - 1021-335X
VL - 14
SP - 415
EP - 419
JO - Oncology Reports
JF - Oncology Reports
IS - 2
ER -