TY - JOUR
T1 - FEZ1/LZTS1 protein expression in ovarian cancer
AU - Califano, Daniela
AU - Pignata, Sandro
AU - Pisano, Carmela
AU - Greggi, Stefano
AU - Laurelli, Giuseppe
AU - Losito, Nunzia Simona
AU - Ottaiano, Alessandro
AU - Gallipoli, Adolfo
AU - Pasquinelli, Rosa
AU - De Simone, Veronica
AU - Cirombella, Roberto
AU - Fusco, Alfredo
AU - Chiappetta, Gennaro
PY - 2010/2
Y1 - 2010/2
N2 - The FEZ1/LZTS1 (FEZ1) gene maps to chromosome 8p22 and is frequently altered in human cancer. FEZ1 has been proposed as a candidate tumour suppressor gene and its loss may contribute to tumour progression. We have analysed the expression of FEZ1 protein in tissues from ovarian carcinomas in relation to clinico-pathological variables, response to chemotherapy and disease-free and overall survival. FEZ1 status was assessed by immunohistochemistry. Cytoplasmic staining for FEZ1 protein was absent or drastically reduced in 38% of tumours. FEZ1 protein expression was not related to tumour grade, histotype, disease-free survival, or overall survival.Onthe contrary, it was significantly correlated with age and with FIGO stage of disease. This finding indicates that FEZ1 is involved in ovarian carcinogenesis. Moreover, loss of FEZ1 protein significantly predicted a complete treatment response in patients who received taxane-based chemotherapy. In conclusion, the reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma.
AB - The FEZ1/LZTS1 (FEZ1) gene maps to chromosome 8p22 and is frequently altered in human cancer. FEZ1 has been proposed as a candidate tumour suppressor gene and its loss may contribute to tumour progression. We have analysed the expression of FEZ1 protein in tissues from ovarian carcinomas in relation to clinico-pathological variables, response to chemotherapy and disease-free and overall survival. FEZ1 status was assessed by immunohistochemistry. Cytoplasmic staining for FEZ1 protein was absent or drastically reduced in 38% of tumours. FEZ1 protein expression was not related to tumour grade, histotype, disease-free survival, or overall survival.Onthe contrary, it was significantly correlated with age and with FIGO stage of disease. This finding indicates that FEZ1 is involved in ovarian carcinogenesis. Moreover, loss of FEZ1 protein significantly predicted a complete treatment response in patients who received taxane-based chemotherapy. In conclusion, the reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma.
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U2 - 10.1002/jcp.21962
DO - 10.1002/jcp.21962
M3 - Article
C2 - 19885841
AN - SCOPUS:73349110980
SN - 0021-9541
VL - 222
SP - 382
EP - 386
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
IS - 2
ER -