Fenoldopam and acute renal failure in cardiac surgery: A meta-analysis of randomized placebo-controlled trials

Alberto Zangrillo, Giuseppe G L Biondi-Zoccai, Elena Frati, Remo Daniel Covello, Luca Cabrini, Fabio Guarracino, Laura Ruggeri, Tiziana Bove, Elena Bignami, Giovanni Landoni

Research output: Contribution to journalArticlepeer-review


Objective: Because at present no pharmacologic prevention or treatment of acute kidney injury seems to be available, the authors updated a meta-analysis to investigate the effects of fenoldopam in reducing acute kidney injury in patients undergoing cardiac surgery, focusing on randomized placebo-controlled studies only. Design: A meta-analysis of randomized, placebo-controlled trials. Setting: Hospitals. Participants: A total of 440 patients from 6 studies were included in the analysis. Interventions: None. The ability of fenoldopam to reduce acute kidney injury in the perioperative period when compared with placebo was investigated. Measurements and Main Results: Google Scholar and PubMed were searched (updated January 1, 2012). Authors and external experts were contacted. Pooled estimates showed that fenoldopam consistently and significantly reduced the risk of acute kidney injury (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.23-0.74; p = 0.003), with a higher rate of hypotensive episodes and/or use of vasopressors (30/109 [27.5%] v 21/112 [18.8%]; OR = 2.09; 95% CI, 0.98-4.47; p = 0.06) and no effect on renal replacement therapy, survival, and length of intensive care unit or hospital stay. Conclusions: This analysis suggests that fenoldopam reduces acute kidney injury in patients undergoing cardiac surgery. Because the number of the enrolled patients was small and there was no effect on renal replacement therapy or survival, a large, multicenter, and appropriately powered trial is needed to confirm these promising results.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number3
Publication statusPublished - Jun 2012


  • acute kidney injury
  • acute renal failure
  • cardiac anesthesia
  • cardiac surgery
  • fenodopam
  • intensive care
  • renal replacement therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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