Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Amalia Gastaldelli; Michaela Kozakova; Kurt Höjlund; Allan Flyvbjerg; Angela Favuzzi; Asimina Mitrakou; Beverly Balkau; R. J. Heine; J. Dekker; G. Nijpels; W. Boorsma; S. Tournis; K. Kyriakopoulou; P. Thomakos; N. Lalic; K. Lalic; A. Jotic; L. Lukic; M. Civcic; J. Nolan; T. P. Yeow; M. Murphy; C. DeLong; G. Neary; M. P. Colgan; M. Hatunic; T. Konrad; H. Bohles; S. Fuellert; F. Baer; H. Zuchhold; A. Golay; E. Harsch Bobbioni; V. Barthassat; V. Makoundou; T. N O Lehmann; T. Merminod; J. R. Petrie; C. Perry; F. Neary; C. MacDougall; K. Shields; L. Malcolm; M. Laakso; U. Salmenniemi; A. Aura; R. Raisanen; U. Ruotsalainen; T. Sistonen; M. Laitinen; H. Saloranta; S. W. Coppack; N. McIntosh; P. Khadobaksh; M. Laville; F. Bonnet; A. Brac de la Perriere; C. Louche-Pelissier; C. Maitrepierre; J. Peyrat; A. Serusclat; R. Gabriel; E. M. Sańchez; R. Carraro; A. Friera; B. Novella; P. Nilsson; M. Persson; G. OÖstling; O. Melander; P. Burri; P. M. Piatti; L. D. Monti; E. Setola; E. Galluccio; F. Minicucci; A. Colleluori; M. Walker; I. M. Ibrahim; M. Jayapaul; D. Carman; K. Short; Y. McGrady; D. Richardson; H. Beck-Nielsen; P. Staehr; K. Hojlund; V. Vestergaard; C. Olsen; L. Hansen; G. B. Bolli; F. Porcellati; C. Fanelli; P. Lucidi; F. Calcinaro; A. Saturni; E. Ferrannini; A. Natali; E. Muscelli; S. Pinnola; M. Kozakova; G. Mingrone; C. Guidone; A. Favuzzi; P. Di Rocco; C. Anderwald; M. Bischof; M. Promintzer; M. Krebs; M. Mandl; A. Hofer; A. Luger; W. Waldhaäusl; M. Roden; S. W. Coppack; J. M. Dekker; A. Mari; M. Walker; P. Gaffney; G. Boran; A. Kok; J. Dekker; S. Patel; D. Ciociaro; M. T. Guillanneuf; L. Mhamdi; G. Pacini; C. Cavaggion; S. A. Hills; L. Landucci; L. Mota

doi:10.1002/hep.22845

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Amalia Gastaldelli, Michaela Kozakova, Kurt Höjlund, Allan Flyvbjerg, Angela Favuzzi, Asimina Mitrakou, Beverly Balkau, R. J. Heine, J. Dekker, G. Nijpels, W. Boorsma, S. Tournis, K. Kyriakopoulou, P. Thomakos, N. Lalic, K. Lalic, A. Jotic, L. Lukic, M. Civcic, J. NolanT. P. Yeow, M. Murphy, C. DeLong, G. Neary, M. P. Colgan, M. Hatunic, T. Konrad, H. Bohles, S. Fuellert, F. Baer, H. Zuchhold, A. Golay, E. Harsch Bobbioni, V. Barthassat, V. Makoundou, T. N O Lehmann, T. Merminod, J. R. Petrie, C. Perry, F. Neary, C. MacDougall, K. Shields, L. Malcolm, M. Laakso, U. Salmenniemi, A. Aura, R. Raisanen, U. Ruotsalainen, T. Sistonen, M. Laitinen, H. Saloranta, S. W. Coppack, N. McIntosh, P. Khadobaksh, M. Laville, F. Bonnet, A. Brac de la Perriere, C. Louche-Pelissier, C. Maitrepierre, J. Peyrat, A. Serusclat, R. Gabriel, E. M. Sańchez, R. Carraro, A. Friera, B. Novella, P. Nilsson, M. Persson, G. OÖstling, O. Melander, P. Burri, P. M. Piatti, L. D. Monti, E. Setola, E. Galluccio, F. Minicucci, A. Colleluori, M. Walker, I. M. Ibrahim, M. Jayapaul, D. Carman, K. Short, Y. McGrady, D. Richardson, H. Beck-Nielsen, P. Staehr, K. Hojlund, V. Vestergaard, C. Olsen, L. Hansen, G. B. Bolli, F. Porcellati, C. Fanelli, P. Lucidi, F. Calcinaro, A. Saturni, E. Ferrannini, A. Natali, E. Muscelli, S. Pinnola, M. Kozakova, G. Mingrone, C. Guidone, A. Favuzzi, P. Di Rocco, C. Anderwald, M. Bischof, M. Promintzer, M. Krebs, M. Mandl, A. Hofer, A. Luger, W. Waldhaäusl, M. Roden, S. W. Coppack, J. M. Dekker, A. Mari, M. Walker, P. Gaffney, G. Boran, A. Kok, J. Dekker, S. Patel, D. Ciociaro, M. T. Guillanneuf, L. Mhamdi, G. Pacini, C. Cavaggion, S. A. Hills, L. Landucci, L. Mota

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI;>60, likelihood>78% presence FL; FLI91%absence of FL). Subjects were divided into three groups: G1: FLI60 (n=234), G2: intermediate group (n=465). Compared to G1,G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3= 0.64±0.08 versusG1=0.58±0.08mm,P

Original language	English
Pages (from-to)	1537-1544
Number of pages	8
Journal	Hepatology
Volume	49
Issue number	5
DOIs	https://doi.org/10.1002/hep.22845
Publication status	Published - May 2009

ASJC Scopus subject areas

Hepatology
Medicine(all)

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10.1002/hep.22845

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Gastaldelli, A., Kozakova, M., Höjlund, K., Flyvbjerg, A., Favuzzi, A., Mitrakou, A., Balkau, B., Heine, R. J., Dekker, J., Nijpels, G., Boorsma, W., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., ... Mota, L. (2009). Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology, 49(5), 1537-1544. https://doi.org/10.1002/hep.22845

Gastaldelli, A, Kozakova, M, Höjlund, K, Flyvbjerg, A, Favuzzi, A, Mitrakou, A, Balkau, B, Heine, RJ, Dekker, J, Nijpels, G, Boorsma, W, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, TP, Murphy, M, DeLong, C, Neary, G, Colgan, MP, Hatunic, M, Konrad, T, Bohles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, TNO, Merminod, T, Petrie, JR, Perry, C, Neary, F, MacDougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, SW, McIntosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sańchez, EM, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, OÖstling, G, Melander, O, Burri, P, Piatti, PM , Monti, LD, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, IM, Jayapaul, M, Carman, D, Short, K, McGrady, Y, Richardson, D, Beck-Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, GB, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhaäusl, W, Roden, M, Coppack, SW, Dekker, JM, Mari, A, Walker, M, Gaffney, P, Boran, G, Kok, A, Dekker, J, Patel, S, Ciociaro, D, Guillanneuf, MT, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, SA, Landucci, L & Mota, L 2009, 'Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population', Hepatology, vol. 49, no. 5, pp. 1537-1544. https://doi.org/10.1002/hep.22845

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title = "Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population",

abstract = "Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI;>60, likelihood>78% presence FL; FLI91%absence of FL). Subjects were divided into three groups: G1: FLI60 (n=234), G2: intermediate group (n=465). Compared to G1,G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3= 0.64±0.08 versusG1=0.58±0.08mm,P",

author = "Amalia Gastaldelli and Michaela Kozakova and Kurt H{\"o}jlund and Allan Flyvbjerg and Angela Favuzzi and Asimina Mitrakou and Beverly Balkau and Heine, {R. J.} and J. Dekker and G. Nijpels and W. Boorsma and S. Tournis and K. Kyriakopoulou and P. Thomakos and N. Lalic and K. Lalic and A. Jotic and L. Lukic and M. Civcic and J. Nolan and Yeow, {T. P.} and M. Murphy and C. DeLong and G. Neary and Colgan, {M. P.} and M. Hatunic and T. Konrad and H. Bohles and S. Fuellert and F. Baer and H. Zuchhold and A. Golay and {Harsch Bobbioni}, E. and V. Barthassat and V. Makoundou and Lehmann, {T. N O} and T. Merminod and Petrie, {J. R.} and C. Perry and F. Neary and C. MacDougall and K. Shields and L. Malcolm and M. Laakso and U. Salmenniemi and A. Aura and R. Raisanen and U. Ruotsalainen and T. Sistonen and M. Laitinen and H. Saloranta and Coppack, {S. W.} and N. McIntosh and P. Khadobaksh and M. Laville and F. Bonnet and {Brac de la Perriere}, A. and C. Louche-Pelissier and C. Maitrepierre and J. Peyrat and A. Serusclat and R. Gabriel and Sa{\'n}chez, {E. M.} and R. Carraro and A. Friera and B. Novella and P. Nilsson and M. Persson and G. O{\"O}stling and O. Melander and P. Burri and Piatti, {P. M.} and Monti, {L. D.} and E. Setola and E. Galluccio and F. Minicucci and A. Colleluori and M. Walker and Ibrahim, {I. M.} and M. Jayapaul and D. Carman and K. Short and Y. McGrady and D. Richardson and H. Beck-Nielsen and P. Staehr and K. Hojlund and V. Vestergaard and C. Olsen and L. Hansen and Bolli, {G. B.} and F. Porcellati and C. Fanelli and P. Lucidi and F. Calcinaro and A. Saturni and E. Ferrannini and A. Natali and E. Muscelli and S. Pinnola and M. Kozakova and G. Mingrone and C. Guidone and A. Favuzzi and {Di Rocco}, P. and C. Anderwald and M. Bischof and M. Promintzer and M. Krebs and M. Mandl and A. Hofer and A. Luger and W. Waldha{\"a}usl and M. Roden and Coppack, {S. W.} and Dekker, {J. M.} and A. Mari and M. Walker and P. Gaffney and G. Boran and A. Kok and J. Dekker and S. Patel and D. Ciociaro and Guillanneuf, {M. T.} and L. Mhamdi and G. Pacini and C. Cavaggion and Hills, {S. A.} and L. Landucci and L. Mota",

year = "2009",

month = may,

doi = "10.1002/hep.22845",

language = "English",

volume = "49",

pages = "1537--1544",

journal = "Hepatology",

issn = "0270-9139",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

AU - Gastaldelli, Amalia

AU - Kozakova, Michaela

AU - Höjlund, Kurt

AU - Flyvbjerg, Allan

AU - Favuzzi, Angela

AU - Mitrakou, Asimina

AU - Balkau, Beverly

AU - Heine, R. J.

AU - Dekker, J.

AU - Nijpels, G.

AU - Boorsma, W.

AU - Tournis, S.

AU - Kyriakopoulou, K.

AU - Thomakos, P.

AU - Lalic, N.

AU - Lalic, K.

AU - Jotic, A.

AU - Lukic, L.

AU - Civcic, M.

AU - Nolan, J.

AU - Yeow, T. P.

AU - Murphy, M.

AU - DeLong, C.

AU - Neary, G.

AU - Colgan, M. P.

AU - Hatunic, M.

AU - Konrad, T.

AU - Bohles, H.

AU - Fuellert, S.

AU - Baer, F.

AU - Zuchhold, H.

AU - Golay, A.

AU - Harsch Bobbioni, E.

AU - Barthassat, V.

AU - Makoundou, V.

AU - Lehmann, T. N O

AU - Merminod, T.

AU - Petrie, J. R.

AU - Perry, C.

AU - Neary, F.

AU - MacDougall, C.

AU - Shields, K.

AU - Malcolm, L.

AU - Laakso, M.

AU - Salmenniemi, U.

AU - Aura, A.

AU - Raisanen, R.

AU - Ruotsalainen, U.

AU - Sistonen, T.

AU - Laitinen, M.

AU - Saloranta, H.

AU - Coppack, S. W.

AU - McIntosh, N.

AU - Khadobaksh, P.

AU - Laville, M.

AU - Bonnet, F.

AU - Brac de la Perriere, A.

AU - Louche-Pelissier, C.

AU - Maitrepierre, C.

AU - Peyrat, J.

AU - Serusclat, A.

AU - Gabriel, R.

AU - Sańchez, E. M.

AU - Carraro, R.

AU - Friera, A.

AU - Novella, B.

AU - Nilsson, P.

AU - Persson, M.

AU - OÖstling, G.

AU - Melander, O.

AU - Burri, P.

AU - Piatti, P. M.

AU - Monti, L. D.

AU - Setola, E.

AU - Galluccio, E.

AU - Minicucci, F.

AU - Colleluori, A.

AU - Walker, M.

AU - Ibrahim, I. M.

AU - Jayapaul, M.

AU - Carman, D.

AU - Short, K.

AU - McGrady, Y.

AU - Richardson, D.

AU - Beck-Nielsen, H.

AU - Staehr, P.

AU - Hojlund, K.

AU - Vestergaard, V.

AU - Olsen, C.

AU - Hansen, L.

AU - Bolli, G. B.

AU - Porcellati, F.

AU - Fanelli, C.

AU - Lucidi, P.

AU - Calcinaro, F.

AU - Saturni, A.

AU - Ferrannini, E.

AU - Natali, A.

AU - Muscelli, E.

AU - Pinnola, S.

AU - Kozakova, M.

AU - Mingrone, G.

AU - Guidone, C.

AU - Favuzzi, A.

AU - Di Rocco, P.

AU - Anderwald, C.

AU - Bischof, M.

AU - Promintzer, M.

AU - Krebs, M.

AU - Mandl, M.

AU - Hofer, A.

AU - Luger, A.

AU - Waldhaäusl, W.

AU - Roden, M.

AU - Coppack, S. W.

AU - Dekker, J. M.

AU - Mari, A.

AU - Walker, M.

AU - Gaffney, P.

AU - Boran, G.

AU - Kok, A.

AU - Dekker, J.

AU - Patel, S.

AU - Ciociaro, D.

AU - Guillanneuf, M. T.

AU - Mhamdi, L.

AU - Pacini, G.

AU - Cavaggion, C.

AU - Hills, S. A.

AU - Landucci, L.

AU - Mota, L.

PY - 2009/5

Y1 - 2009/5

N2 - Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI;>60, likelihood>78% presence FL; FLI91%absence of FL). Subjects were divided into three groups: G1: FLI60 (n=234), G2: intermediate group (n=465). Compared to G1,G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3= 0.64±0.08 versusG1=0.58±0.08mm,P

AB - Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI;>60, likelihood>78% presence FL; FLI91%absence of FL). Subjects were divided into three groups: G1: FLI60 (n=234), G2: intermediate group (n=465). Compared to G1,G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3= 0.64±0.08 versusG1=0.58±0.08mm,P

UR - http://www.scopus.com/inward/record.url?scp=66149119340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149119340&partnerID=8YFLogxK

U2 - 10.1002/hep.22845

DO - 10.1002/hep.22845

M3 - Article

C2 - 19291789

AN - SCOPUS:66149119340

SN - 0270-9139

VL - 49

SP - 1537

EP - 1544

JO - Hepatology

JF - Hepatology

IS - 5

ER -

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

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