Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Amalia Gastaldelli, Michaela Kozakova, Kurt Höjlund, Allan Flyvbjerg, Angela Favuzzi, Asimina Mitrakou, Beverly Balkau, R. J. Heine, J. Dekker, G. Nijpels, W. Boorsma, S. Tournis, K. Kyriakopoulou, P. Thomakos, N. Lalic, K. Lalic, A. Jotic, L. Lukic, M. Civcic, J. NolanT. P. Yeow, M. Murphy, C. DeLong, G. Neary, M. P. Colgan, M. Hatunic, T. Konrad, H. Bohles, S. Fuellert, F. Baer, H. Zuchhold, A. Golay, E. Harsch Bobbioni, V. Barthassat, V. Makoundou, T. N O Lehmann, T. Merminod, J. R. Petrie, C. Perry, F. Neary, C. MacDougall, K. Shields, L. Malcolm, M. Laakso, U. Salmenniemi, A. Aura, R. Raisanen, U. Ruotsalainen, T. Sistonen, M. Laitinen, H. Saloranta, S. W. Coppack, N. McIntosh, P. Khadobaksh, M. Laville, F. Bonnet, A. Brac de la Perriere, C. Louche-Pelissier, C. Maitrepierre, J. Peyrat, A. Serusclat, R. Gabriel, E. M. Sańchez, R. Carraro, A. Friera, B. Novella, P. Nilsson, M. Persson, G. OÖstling, O. Melander, P. Burri, P. M. Piatti, L. D. Monti, E. Setola, E. Galluccio, F. Minicucci, A. Colleluori, M. Walker, I. M. Ibrahim, M. Jayapaul, D. Carman, K. Short, Y. McGrady, D. Richardson, H. Beck-Nielsen, P. Staehr, K. Hojlund, V. Vestergaard, C. Olsen, L. Hansen, G. B. Bolli, F. Porcellati, C. Fanelli, P. Lucidi, F. Calcinaro, A. Saturni, E. Ferrannini, A. Natali, E. Muscelli, S. Pinnola, M. Kozakova, G. Mingrone, C. Guidone, A. Favuzzi, P. Di Rocco, C. Anderwald, M. Bischof, M. Promintzer, M. Krebs, M. Mandl, A. Hofer, A. Luger, W. Waldhaäusl, M. Roden, S. W. Coppack, J. M. Dekker, A. Mari, M. Walker, P. Gaffney, G. Boran, A. Kok, J. Dekker, S. Patel, D. Ciociaro, M. T. Guillanneuf, L. Mhamdi, G. Pacini, C. Cavaggion, S. A. Hills, L. Landucci, L. Mota

Research output: Contribution to journalArticlepeer-review


Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI;>60, likelihood>78% presence FL; FLI91%absence of FL). Subjects were divided into three groups: G1: FLI60 (n=234), G2: intermediate group (n=465). Compared to G1,G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3= 0.64±0.08 versusG1=0.58±0.08mm,P

Original languageEnglish
Pages (from-to)1537-1544
Number of pages8
Issue number5
Publication statusPublished - May 2009

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)


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