Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.

Raffaele Bruno; Paolo Sacchi; Massimo Puoti; Valentina Ciappina; Cristina Zocchetti; Enrico Brunetti; Elena Maffezzini; Anna Capelli; Savino F A Patruno; Antonello Malfitano; Gaetano Filice

Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.

Raffaele Bruno, Paolo Sacchi, Massimo Puoti, Valentina Ciappina, Cristina Zocchetti, Enrico Brunetti, Elena Maffezzini, Anna Capelli, Savino F A Patruno, Antonello Malfitano, Gaetano Filice

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART.The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS: We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA

Original language	English
Pages (from-to)	17
Number of pages	1
Journal	BMC Infectious Diseases
Volume	2
Issue number	1
Publication status	Published - Aug 28 2002

ASJC Scopus subject areas

Infectious Diseases

Cite this

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title = "Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.",

abstract = "BACKGROUND: The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART.The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS: We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA ",

author = "Raffaele Bruno and Paolo Sacchi and Massimo Puoti and Valentina Ciappina and Cristina Zocchetti and Enrico Brunetti and Elena Maffezzini and Anna Capelli and Patruno, {Savino F A} and Antonello Malfitano and Gaetano Filice",

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T1 - Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.

AU - Bruno, Raffaele

AU - Sacchi, Paolo

AU - Puoti, Massimo

AU - Ciappina, Valentina

AU - Zocchetti, Cristina

AU - Brunetti, Enrico

AU - Maffezzini, Elena

AU - Capelli, Anna

AU - Patruno, Savino F A

AU - Malfitano, Antonello

AU - Filice, Gaetano

PY - 2002/8/28

Y1 - 2002/8/28

N2 - BACKGROUND: The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART.The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS: We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA

AB - BACKGROUND: The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART.The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS: We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA

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M3 - Article

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JO - BMC Infectious Diseases

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Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.

Abstract

ASJC Scopus subject areas

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