Familial hemiplegic migraine: Clinical features and probable linkage to chromosome 1 in an Italian family

S. Cevoli, G. Pierangeli, L. Monari, M. L. Valentino, P. Bernardoni, M. Mochi, P. Cortelli, P. Montagna

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We describe an Italian family with familial hemiplegic migraine (FHM), subtle cerebellar signs and probable linkage to chromosome 1. FHM is genetically heterogeneous; in about 50% of families it is caused by mutations within the CACNA1A gene on chromosome 19. Linkage to 1q31 and 1q21-23 has also been established. Other families do not link either to chromosome 19 or 1. Chromosome 19-linked FHM may display nystagmus and cerebellar ataxia. Affected family members were neurologically examined; linkage analysis was performed with markers for chromosomes 19p13, 1q21-23 and 1q32. Five family members had hemiplegic migraine, and 3 displayed additional cerebellar signs (scanning speech and nystagmus). In 1 patient, episodes of hemiplegic migraine triggered by mild head trauma. Epilepsy and mental retardation were also found in 1 affected relative each. Lod scores for linkage to 19p13 were negative, while the maximum two-point lod score was 1.81 to 1q21-23. This family with FHM and associated subtle cerebellar signs, epilepsy and mental retardation showed probable linkage to 1q21-23.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalNeurological Sciences
Issue number1
Publication statusPublished - 2002


  • Cerebellar disease
  • Familial hemiplegic migraine
  • Linkage analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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