TY - JOUR
T1 - Factor V (Arg506 → Gln) Mutation in Young Survivors of Myocardial Infarction
AU - Ardissino, Diego
AU - Peyvandi, Flora
AU - Merlini, Piera Angelica
AU - Colombi, Elisabetta
AU - Mannucci, Pier Mannuccio
PY - 1996/5
Y1 - 1996/5
N2 - Many young patients with venous thromboembolic disease are partially resistant to the anticoagulant action of activated protein C as a result of factor V (Arg506 → Gln) mutation. The frequency of this mutation in young patients with arterial thrombotic diseases, such as myocardial infarction, is less well established. We studied 100 young patients with myocardial infarction and 100 age- and sex-matched controls. One patient (1%; 95% CL 0.05-6.2) and two controls (2%; 95% CL 0.3-7.7) were heterozygotes for the mutation; there was no homozygote in either group. Hence, premature myocardial infarction is not associated with heterozygosity for factor V (Arg506 → Gln) mutation.
AB - Many young patients with venous thromboembolic disease are partially resistant to the anticoagulant action of activated protein C as a result of factor V (Arg506 → Gln) mutation. The frequency of this mutation in young patients with arterial thrombotic diseases, such as myocardial infarction, is less well established. We studied 100 young patients with myocardial infarction and 100 age- and sex-matched controls. One patient (1%; 95% CL 0.05-6.2) and two controls (2%; 95% CL 0.3-7.7) were heterozygotes for the mutation; there was no homozygote in either group. Hence, premature myocardial infarction is not associated with heterozygosity for factor V (Arg506 → Gln) mutation.
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M3 - Article
C2 - 8725707
AN - SCOPUS:0029943533
SN - 0340-6245
VL - 75
SP - 701
EP - 702
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 5
ER -