Extrahepatic Manifestations of Hepatitis C Virus

Mauro Viganò, Massimo Colombo

Research output: Contribution to journalArticlepeer-review


Chronic infection with the hepatitis C virus (HCV) is a major cause of liver disease worldwide and is also responsible for extrahepatic manifestations (EHMs) involving the skin, kidneys, salivary glands, eyes, thyroid, and immune system. Mixed cryoglobulinemia is the prototype EHM related to HCV infection. Although these HCV-related EHMs may contribute to significant rates of morbidity affecting patient's quality of life and survival, most of these complications can reverse after HCV eradication by interferon therapy. This notwithstanding, individual patients may have an irreversible injury in various organs that is not reversed by a cure of the HCV infection.

Original languageEnglish
Pages (from-to)775-791
Number of pages17
JournalGastroenterology Clinics of North America
Issue number4
Publication statusPublished - Dec 1 2015


  • B-cell non-Hodgkin lymphoma
  • Cryoglobulins
  • Extrahepatic manifestations
  • HCV
  • Interferon

ASJC Scopus subject areas

  • Gastroenterology


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