TY - JOUR
T1 - Expression profiles in malignant fibrous histiocytomas
T2 - Clues for differentiating 'spindle cell' and 'pleomorphic' subtypes
AU - Scapolan, Martina
AU - Perin, Tiziana
AU - Wassermann, Bruna
AU - Canzonieri, Vincenzo
AU - Colombatti, Alfonso
AU - Italia, Fabrizio
AU - Spessotto, Paola
PY - 2008/1
Y1 - 2008/1
N2 - We analysed 21 samples of malignant fibrous histiocytoma (MFH) distinguished into the two principal morphological categories ('spindle cell' and the 'pleomorphic' subtypes). The aim of our study was to verify if a distinction between the two subclasses of MFH in terms of expression/activation of protein profiles could support and extend the morphological criteria. For this purpose, we carried out an immunohistochemical and immunoblotting analysis of proteins that could be relevant in sarcoma biology and potential diagnostic and therapeutical targets such as matrix metalloproteinases (MMPs) and molecules related to adhesive and proliferative properties. Our analysis revealed that MMP-1, MMP-9 expression and p27(kip1) cytoplasmic localisation can be considered valid parameters in the classification and potential explanation of the aggressive behaviour of this non-homogeneous group of MFH.
AB - We analysed 21 samples of malignant fibrous histiocytoma (MFH) distinguished into the two principal morphological categories ('spindle cell' and the 'pleomorphic' subtypes). The aim of our study was to verify if a distinction between the two subclasses of MFH in terms of expression/activation of protein profiles could support and extend the morphological criteria. For this purpose, we carried out an immunohistochemical and immunoblotting analysis of proteins that could be relevant in sarcoma biology and potential diagnostic and therapeutical targets such as matrix metalloproteinases (MMPs) and molecules related to adhesive and proliferative properties. Our analysis revealed that MMP-1, MMP-9 expression and p27(kip1) cytoplasmic localisation can be considered valid parameters in the classification and potential explanation of the aggressive behaviour of this non-homogeneous group of MFH.
KW - Malignant fibrous histiocytoma
KW - MMP-1
KW - MMP-9
KW - p27(kip1)
UR - http://www.scopus.com/inward/record.url?scp=38349032638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349032638&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2007.10.012
DO - 10.1016/j.ejca.2007.10.012
M3 - Article
C2 - 18054831
AN - SCOPUS:38349032638
SN - 0959-8049
VL - 44
SP - 298
EP - 309
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 2
ER -