TY - JOUR
T1 - Expression of mouse and human fibronectin in mouse-human somatic cell hybrids
AU - Zardi, Luciano
AU - Carnemolla, Barbara
AU - Croce, Carlo M.
PY - 1979
Y1 - 1979
N2 - Using antisera to the human and mouse fibronectin (Large External Transformation Sensitive (LETS) protein), we studied the expression of mouse and human fibronectin in mouse-human somatic cell hybrids segregating either human or mouse chromosomes. The results of this study show that, in such somatic cell hybrids, mouse and human fibronectin are coexpressed. In addition, activation of the synthesis of mouse fibronectin was observed in somatic cell hybrids between mouse peritoneal macrophages, which do not produce detectable amounts of fibronectin, and either SV40-transformed human cells or cells derived from a human fibrosarcoma.
AB - Using antisera to the human and mouse fibronectin (Large External Transformation Sensitive (LETS) protein), we studied the expression of mouse and human fibronectin in mouse-human somatic cell hybrids segregating either human or mouse chromosomes. The results of this study show that, in such somatic cell hybrids, mouse and human fibronectin are coexpressed. In addition, activation of the synthesis of mouse fibronectin was observed in somatic cell hybrids between mouse peritoneal macrophages, which do not produce detectable amounts of fibronectin, and either SV40-transformed human cells or cells derived from a human fibrosarcoma.
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U2 - 10.1016/0014-4827(79)90174-5
DO - 10.1016/0014-4827(79)90174-5
M3 - Article
C2 - 104874
AN - SCOPUS:0018341714
SN - 0014-4827
VL - 118
SP - 435
EP - 438
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
ER -