Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Carmela Giachino; Maurizio Viale; Graziella Vecchio

doi:10.1002/slct.201903774

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Carmela Giachino, Maurizio Viale, Graziella Vecchio

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on ?-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.

Original language	English
Pages (from-to)	13025-13028
Number of pages	4
Journal	ChemistrySelect
Volume	4
Issue number	44
DOIs	https://doi.org/10.1002/slct.201903774
Publication status	Published - 2019

Keywords

arginine
biotin
cancer
doxorubicin
tumor

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10.1002/slct.201903774

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title = "Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting",

abstract = "Abstract Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on ?-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.",

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author = "Carmela Giachino and Maurizio Viale and Graziella Vecchio",

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AU - Giachino, Carmela

AU - Viale, Maurizio

AU - Vecchio, Graziella

N1 - doi: 10.1002/slct.201903774

PY - 2019

Y1 - 2019

N2 - Abstract Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on ?-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.

AB - Abstract Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on ?-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.

KW - arginine

KW - biotin

KW - cancer

KW - doxorubicin

KW - tumor

U2 - 10.1002/slct.201903774

DO - 10.1002/slct.201903774

M3 - Article

SN - 2365-6549

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EP - 13028

JO - ChemistrySelect

JF - ChemistrySelect

IS - 44

ER -

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Abstract

Keywords

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