Expanding the clinical spectrum of POMT1 phenotype

A. D&apos;Amico; A. Tessa; C. Bruno; S. Petrini; R. Biancheri; M. Pane; M. Pedemonte; E. Ricci; A. Falace; A. Rossi; E. Mercuri; F. M. Santorelli; E. Bertini

doi:10.1212/01.wnl.0000216145.66476.36

Expanding the clinical spectrum of POMT1 phenotype

A. D'Amico, A. Tessa, C. Bruno, S. Petrini, R. Biancheri, M. Pane, M. Pedemonte, E. Ricci, A. Falace, A. Rossi, E. Mercuri, F. M. Santorelli, E. Bertini

Research output: Contribution to journal › Article › peer-review

Abstract

Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes.

Original language	English
Pages (from-to)	1564-1567
Number of pages	4
Journal	Neurology
Volume	66
Issue number	10
DOIs	https://doi.org/10.1212/01.wnl.0000216145.66476.36
Publication status	Published - May 2006

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes.",

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AU - D'Amico, A.

AU - Tessa, A.

AU - Bruno, C.

AU - Petrini, S.

AU - Biancheri, R.

AU - Pane, M.

AU - Pedemonte, M.

AU - Ricci, E.

AU - Falace, A.

AU - Rossi, A.

AU - Mercuri, E.

AU - Santorelli, F. M.

AU - Bertini, E.

PY - 2006/5

Y1 - 2006/5

N2 - Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes.

AB - Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes.

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Expanding the clinical spectrum of POMT1 phenotype

Abstract

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