Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis

Fernando M. Reis; Anna M. Di Blasio; Pasquale Florio; Guido Ambrosini; Carla Di Loreto; Felice Petraglia

doi:10.1016/S0015-0282(00)01720-9

Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis

Fernando M. Reis, Anna M. Di Blasio, Pasquale Florio, Guido Ambrosini, Carla Di Loreto, Felice Petraglia

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; immunostaining of α and βA subunits in ovarian endometrioma; α and βA gene expression in cultured endometriotic cells compared with normal endometrium. Result(s): Inhibin A and activin A concentrations in the cystic fluid were slightly higher than in peritoneal fluid and significantly higher than in serum (P

Original language	English
Pages (from-to)	367-373
Number of pages	7
Journal	Fertility and Sterility
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/S0015-0282(00)01720-9
Publication status	Published - 2001

Keywords

Activin
Endometriosis
Inhibin
Ovarian cyst
Ovary

ASJC Scopus subject areas

Obstetrics and Gynaecology

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10.1016/S0015-0282(00)01720-9

Cite this

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title = "Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis",

abstract = "Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; immunostaining of α and βA subunits in ovarian endometrioma; α and βA gene expression in cultured endometriotic cells compared with normal endometrium. Result(s): Inhibin A and activin A concentrations in the cystic fluid were slightly higher than in peritoneal fluid and significantly higher than in serum (P",

keywords = "Activin, Endometriosis, Inhibin, Ovarian cyst, Ovary",

author = "Reis, {Fernando M.} and {Di Blasio}, {Anna M.} and Pasquale Florio and Guido Ambrosini and {Di Loreto}, Carla and Felice Petraglia",

year = "2001",

doi = "10.1016/S0015-0282(00)01720-9",

language = "English",

volume = "75",

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T1 - Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis

AU - Reis, Fernando M.

AU - Di Blasio, Anna M.

AU - Florio, Pasquale

AU - Ambrosini, Guido

AU - Di Loreto, Carla

AU - Petraglia, Felice

PY - 2001

Y1 - 2001

N2 - Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; immunostaining of α and βA subunits in ovarian endometrioma; α and βA gene expression in cultured endometriotic cells compared with normal endometrium. Result(s): Inhibin A and activin A concentrations in the cystic fluid were slightly higher than in peritoneal fluid and significantly higher than in serum (P

AB - Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; immunostaining of α and βA subunits in ovarian endometrioma; α and βA gene expression in cultured endometriotic cells compared with normal endometrium. Result(s): Inhibin A and activin A concentrations in the cystic fluid were slightly higher than in peritoneal fluid and significantly higher than in serum (P

KW - Activin

KW - Endometriosis

KW - Inhibin

KW - Ovarian cyst

KW - Ovary

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Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis

Abstract

Keywords

ASJC Scopus subject areas

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