Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

J. Tillmann; K. Ashwood; M. Absoud; S. Bölte; F. Bonnet-Brilhault; J. K. Buitelaar; S. Calderoni; R. Calvo; R. Canal-Bedia; R. Canitano; A. De Bildt; M. Gomot; P. J. Hoekstra; A. Kaale; H. McConachie; D. G. Murphy; A. Narzisi; I. Oosterling; M. Pejovic-Milovancevic; A. M. Persico; O. Puig; H. Roeyers; N. Rommelse; R. Sacco; V. Scandurra; A. C. Stanfield; E. Zander; T. Charman

doi:10.1007/s10803-018-3510-4

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

J. Tillmann, K. Ashwood, M. Absoud, S. Bölte, F. Bonnet-Brilhault, J. K. Buitelaar, S. Calderoni, R. Calvo, R. Canal-Bedia, R. Canitano, A. De Bildt, M. Gomot, P. J. Hoekstra, A. Kaale, H. McConachie, D. G. Murphy, A. Narzisi, I. Oosterling, M. Pejovic-Milovancevic, A. M. PersicoO. Puig, H. Roeyers, N. Rommelse, R. Sacco, V. Scandurra, A. C. Stanfield, E. Zander, T. Charman

Fondazione Stella Maris

Research output: Contribution to journal › Article › peer-review

Abstract

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

Original language	English
Pages (from-to)	2490-2505
Number of pages	16
Journal	Journal of Autism and Developmental Disorders
Volume	48
Issue number	7
DOIs	https://doi.org/10.1007/s10803-018-3510-4
Publication status	Published - Jul 1 2018

Keywords

Age
Autism Spectrum Disorder
Phenotype
Sex
Symptom severity

ASJC Scopus subject areas

Developmental and Educational Psychology

Access to Document

10.1007/s10803-018-3510-4

Cite this

Tillmann, J., Ashwood, K., Absoud, M., Bölte, S., Bonnet-Brilhault, F., Buitelaar, J. K., Calderoni, S., Calvo, R., Canal-Bedia, R., Canitano, R., De Bildt, A., Gomot, M., Hoekstra, P. J., Kaale, A., McConachie, H., Murphy, D. G., Narzisi, A., Oosterling, I., Pejovic-Milovancevic, M., ... Charman, T. (2018). Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 48(7), 2490-2505. https://doi.org/10.1007/s10803-018-3510-4

Tillmann, J, Ashwood, K, Absoud, M, Bölte, S, Bonnet-Brilhault, F, Buitelaar, JK, Calderoni, S, Calvo, R, Canal-Bedia, R, Canitano, R, De Bildt, A, Gomot, M, Hoekstra, PJ, Kaale, A, McConachie, H, Murphy, DG, Narzisi, A, Oosterling, I, Pejovic-Milovancevic, M, Persico, AM, Puig, O, Roeyers, H, Rommelse, N, Sacco, R, Scandurra, V, Stanfield, AC, Zander, E & Charman, T 2018, 'Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder', Journal of Autism and Developmental Disorders, vol. 48, no. 7, pp. 2490-2505. https://doi.org/10.1007/s10803-018-3510-4

@article{fdd8e4f44144487faf60b10f4f5bad60,

title = "Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder",

abstract = "Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.",

keywords = "Age, Autism Spectrum Disorder, Phenotype, Sex, Symptom severity",

author = "J. Tillmann and K. Ashwood and M. Absoud and S. B{\"o}lte and F. Bonnet-Brilhault and Buitelaar, {J. K.} and S. Calderoni and R. Calvo and R. Canal-Bedia and R. Canitano and {De Bildt}, A. and M. Gomot and Hoekstra, {P. J.} and A. Kaale and H. McConachie and Murphy, {D. G.} and A. Narzisi and I. Oosterling and M. Pejovic-Milovancevic and Persico, {A. M.} and O. Puig and H. Roeyers and N. Rommelse and R. Sacco and V. Scandurra and Stanfield, {A. C.} and E. Zander and T. Charman",

year = "2018",

month = jul,

day = "1",

doi = "10.1007/s10803-018-3510-4",

language = "English",

volume = "48",

pages = "2490--2505",

journal = "Journal of Autism and Developmental Disorders",

issn = "0162-3257",

publisher = "Springer New York",

number = "7",

}

TY - JOUR

T1 - Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

AU - Tillmann, J.

AU - Ashwood, K.

AU - Absoud, M.

AU - Bölte, S.

AU - Bonnet-Brilhault, F.

AU - Buitelaar, J. K.

AU - Calderoni, S.

AU - Calvo, R.

AU - Canal-Bedia, R.

AU - Canitano, R.

AU - De Bildt, A.

AU - Gomot, M.

AU - Hoekstra, P. J.

AU - Kaale, A.

AU - McConachie, H.

AU - Murphy, D. G.

AU - Narzisi, A.

AU - Oosterling, I.

AU - Pejovic-Milovancevic, M.

AU - Persico, A. M.

AU - Puig, O.

AU - Roeyers, H.

AU - Rommelse, N.

AU - Sacco, R.

AU - Scandurra, V.

AU - Stanfield, A. C.

AU - Zander, E.

AU - Charman, T.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

AB - Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

KW - Age

KW - Autism Spectrum Disorder

KW - Phenotype

KW - Sex

KW - Symptom severity

UR - http://www.scopus.com/inward/record.url?scp=85042222021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042222021&partnerID=8YFLogxK

U2 - 10.1007/s10803-018-3510-4

DO - 10.1007/s10803-018-3510-4

M3 - Article

AN - SCOPUS:85042222021

SN - 0162-3257

VL - 48

SP - 2490

EP - 2505

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 7

ER -

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this