Ethanol toxicity: Role of glutathione

E. Altomare, G. Vendemiale, T. Trizio, G. Palasciano, O. Albano

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Glutathione (GSH), a tripeptide thiol found in virtually all cells, is involved in metabolism, transport and cellular protection. Its role in drug biotransformation and prevention of drug toxicity is well established. However, new information concerning the alteration of GSH metabolism during acute and chronic ethanol toxicity and its possible relationship with lipid peroxidation has been accumulated during recent years. Present knowledge suggests that ethanol or its metabolism may modify the hepatic anti-oxidant balance so that increased peroxidation takes place. In addition, new concepts of ethanol toxicity include the possibility of direct production of free radicals during its metabolism. This review focuses on some recent results relating to the role of ethanol intoxication in the modification of glutathione status in relation to its lipoperoxidative capacity.

Original languageEnglish
Title of host publicationChronic liver damage: proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis. ICS910
EditorsM.U. Dianzani, P. Gentilini, M.U. Dianzani, P. Gentilini
PublisherElsevier Science Publishers B.V.
Number of pages9
ISBN (Print)0444812113
Publication statusPublished - 1990
EventThe Annual Meeting of the Italian National Programme on Liver Cirrhosis -
Duration: Jan 11 1990Jan 13 1990


OtherThe Annual Meeting of the Italian National Programme on Liver Cirrhosis

ASJC Scopus subject areas

  • Medicine(all)


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