Erythema induced by organic solvents: In vivo evaluation of oxygenized and deoxygenized haemoglobin by reflectance spectroscopy

E. Berardesca; P. H. Andersen; P. Bjerring; H. I. Maibach

doi:10.1111/j.1600-0536.1992.tb05190.x

Erythema induced by organic solvents: In vivo evaluation of oxygenized and deoxygenized haemoglobin by reflectance spectroscopy

E. Berardesca, P. H. Andersen, P. Bjerring, H. I. Maibach

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: (i) using a new non-invasive technique capable of evaluating quantitatively and qualitatively the haemoglobin content of the skin (ii) to evaluate delipidization induced by organic solvents. Patients: 11 Caucasians treated for 1 min in a randomized manner on the volar forearm with a mixture of chloroform/methanol (2:1) (CM) and ether/acetone (1:1) (EA) to delipidize the skin. Method: erythema was evaluated by computerized remittance spectroscopy immediately after delipidization and hourly for 2 h. Results: only CM application induced subjectively observed and objectively quantified erythema. Erythema was related to a significant increase in oxygenized haemoglobin content due to dilatation of arterioles in the subpapillary plexus (P

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Contact Dermatitis
Volume	27
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0536.1992.tb05190.x
Publication status	Published - 1992

Keywords

Bioengineering methods
Chloroform/methanol
Erythema
Ether/acetone
Irritation
Organic solvents
Remittance spectroscopy

ASJC Scopus subject areas

Dermatology
Toxicology
Immunology

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10.1111/j.1600-0536.1992.tb05190.x

Cite this

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abstract = "Objective: (i) using a new non-invasive technique capable of evaluating quantitatively and qualitatively the haemoglobin content of the skin (ii) to evaluate delipidization induced by organic solvents. Patients: 11 Caucasians treated for 1 min in a randomized manner on the volar forearm with a mixture of chloroform/methanol (2:1) (CM) and ether/acetone (1:1) (EA) to delipidize the skin. Method: erythema was evaluated by computerized remittance spectroscopy immediately after delipidization and hourly for 2 h. Results: only CM application induced subjectively observed and objectively quantified erythema. Erythema was related to a significant increase in oxygenized haemoglobin content due to dilatation of arterioles in the subpapillary plexus (P",

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AU - Andersen, P. H.

AU - Bjerring, P.

AU - Maibach, H. I.

PY - 1992

Y1 - 1992

N2 - Objective: (i) using a new non-invasive technique capable of evaluating quantitatively and qualitatively the haemoglobin content of the skin (ii) to evaluate delipidization induced by organic solvents. Patients: 11 Caucasians treated for 1 min in a randomized manner on the volar forearm with a mixture of chloroform/methanol (2:1) (CM) and ether/acetone (1:1) (EA) to delipidize the skin. Method: erythema was evaluated by computerized remittance spectroscopy immediately after delipidization and hourly for 2 h. Results: only CM application induced subjectively observed and objectively quantified erythema. Erythema was related to a significant increase in oxygenized haemoglobin content due to dilatation of arterioles in the subpapillary plexus (P

AB - Objective: (i) using a new non-invasive technique capable of evaluating quantitatively and qualitatively the haemoglobin content of the skin (ii) to evaluate delipidization induced by organic solvents. Patients: 11 Caucasians treated for 1 min in a randomized manner on the volar forearm with a mixture of chloroform/methanol (2:1) (CM) and ether/acetone (1:1) (EA) to delipidize the skin. Method: erythema was evaluated by computerized remittance spectroscopy immediately after delipidization and hourly for 2 h. Results: only CM application induced subjectively observed and objectively quantified erythema. Erythema was related to a significant increase in oxygenized haemoglobin content due to dilatation of arterioles in the subpapillary plexus (P

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Erythema induced by organic solvents: In vivo evaluation of oxygenized and deoxygenized haemoglobin by reflectance spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

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