Epileptic seizure associated with intracerebroventricular and intrathecal morphine bolus

Martina F. Kronenberg; Inge Laimer; Carmela Rifici; Leopold Saltuari; Placido Bramanti; Ursula Moriggl; Burghard Norer; Alexandra Kofler

doi:10.1016/S0304-3959(97)00173-5

Epileptic seizure associated with intracerebroventricular and intrathecal morphine bolus

Martina F. Kronenberg, Inge Laimer, Carmela Rifici, Leopold Saltuari, Placido Bramanti, Ursula Moriggl, Burghard Norer, Alexandra Kofler

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

We report on two patients with morphine-related seizures associated with either intrathecal or intracerebroventricular administration. Both patients had a history of malignant tumor and both experienced the seizures following bolus application of morphine, while even higher dosages were well tolerated when continuously infused. Seizures occurred without signs of intoxication. Initiation of intrathecal morphine therapy and bolus application should be performed carefully and only when constant monitoring is provided for at least 12 h. Animal data and possible mechanisms for morphine-related seizures are discussed.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Pain
Volume	75
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3959(97)00173-5
Publication status	Published - Jan 1998

Keywords

Intrathecal
Intraventricular
Morphine
Pain
Seizure

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Neurology
Neuroscience(all)
Pharmacology
Clinical Psychology

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10.1016/S0304-3959(97)00173-5

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title = "Epileptic seizure associated with intracerebroventricular and intrathecal morphine bolus",

abstract = "We report on two patients with morphine-related seizures associated with either intrathecal or intracerebroventricular administration. Both patients had a history of malignant tumor and both experienced the seizures following bolus application of morphine, while even higher dosages were well tolerated when continuously infused. Seizures occurred without signs of intoxication. Initiation of intrathecal morphine therapy and bolus application should be performed carefully and only when constant monitoring is provided for at least 12 h. Animal data and possible mechanisms for morphine-related seizures are discussed.",

keywords = "Intrathecal, Intraventricular, Morphine, Pain, Seizure",

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T1 - Epileptic seizure associated with intracerebroventricular and intrathecal morphine bolus

AU - Kronenberg, Martina F.

AU - Laimer, Inge

AU - Rifici, Carmela

AU - Saltuari, Leopold

AU - Bramanti, Placido

AU - Moriggl, Ursula

AU - Norer, Burghard

AU - Kofler, Alexandra

PY - 1998/1

Y1 - 1998/1

N2 - We report on two patients with morphine-related seizures associated with either intrathecal or intracerebroventricular administration. Both patients had a history of malignant tumor and both experienced the seizures following bolus application of morphine, while even higher dosages were well tolerated when continuously infused. Seizures occurred without signs of intoxication. Initiation of intrathecal morphine therapy and bolus application should be performed carefully and only when constant monitoring is provided for at least 12 h. Animal data and possible mechanisms for morphine-related seizures are discussed.

AB - We report on two patients with morphine-related seizures associated with either intrathecal or intracerebroventricular administration. Both patients had a history of malignant tumor and both experienced the seizures following bolus application of morphine, while even higher dosages were well tolerated when continuously infused. Seizures occurred without signs of intoxication. Initiation of intrathecal morphine therapy and bolus application should be performed carefully and only when constant monitoring is provided for at least 12 h. Animal data and possible mechanisms for morphine-related seizures are discussed.

KW - Intrathecal

KW - Intraventricular

KW - Morphine

KW - Pain

KW - Seizure

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ER -

Epileptic seizure associated with intracerebroventricular and intrathecal morphine bolus

Abstract

Keywords

ASJC Scopus subject areas

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