Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects

Bruno De Bernardi; Walentyna Balwierz; Joanna Bejent; Susan L. Cohn; Maria Luisa Garrè; Tomoko Iehara; Dominique Plantaz; Thorsten Simon; Paola Angelini; Armando Cama; Wendy B. London; Kim Kramer; Howard M. Katzenstein; Paolo Tortori-Donati; Andrea Rossi; Giulio J. D'Angio; Audrey E. Evans

doi:10.1016/j.canlet.2005.01.053

Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects

Bruno De Bernardi, Walentyna Balwierz, Joanna Bejent, Susan L. Cohn, Maria Luisa Garrè, Tomoko Iehara, Dominique Plantaz, Thorsten Simon, Paola Angelini, Armando Cama, Wendy B. London, Kim Kramer, Howard M. Katzenstein, Paolo Tortori-Donati, Andrea Rossi, Giulio J. D'Angio, Audrey E. Evans

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inadequate treatment, severe, permanent neurological compromise may ensue. Surprisingly enough, remarkable disagreements still exist regarding its optimal treatment and the related literature provide contrasting indications at this respect. The neurosurgical and the chemotherapeutic approaches have equally convinced supporters, while the use of radiation therapy is uncommon, possibly without good reasons. This mini-review intends to report the clinical experiences of the major Paediatric Oncology Groups with the aim to collect as many data as possible in the perspective of establishing common guidelines for proper diagnosing and treatment of this important complication.

Original language	English
Pages (from-to)	283-299
Number of pages	17
Journal	Cancer Letters
Volume	228
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2005.01.053
Publication status	Published - Oct 18 2005

Keywords

Epidural compression
Late effects
Neuroblastoma
Spinal cord compression

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/j.canlet.2005.01.053

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De Bernardi, B., Balwierz, W., Bejent, J., Cohn, S. L., Garrè, M. L., Iehara, T., Plantaz, D., Simon, T., Angelini, P., Cama, A., London, W. B., Kramer, K., Katzenstein, H. M., Tortori-Donati, P., Rossi, A., D'Angio, G. J., & Evans, A. E. (2005). Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects. Cancer Letters, 228(1-2), 283-299. https://doi.org/10.1016/j.canlet.2005.01.053

De Bernardi, B, Balwierz, W, Bejent, J, Cohn, SL, Garrè, ML, Iehara, T, Plantaz, D, Simon, T, Angelini, P, Cama, A, London, WB, Kramer, K, Katzenstein, HM, Tortori-Donati, P, Rossi, A, D'Angio, GJ & Evans, AE 2005, 'Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects', Cancer Letters, vol. 228, no. 1-2, pp. 283-299. https://doi.org/10.1016/j.canlet.2005.01.053

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abstract = "The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inadequate treatment, severe, permanent neurological compromise may ensue. Surprisingly enough, remarkable disagreements still exist regarding its optimal treatment and the related literature provide contrasting indications at this respect. The neurosurgical and the chemotherapeutic approaches have equally convinced supporters, while the use of radiation therapy is uncommon, possibly without good reasons. This mini-review intends to report the clinical experiences of the major Paediatric Oncology Groups with the aim to collect as many data as possible in the perspective of establishing common guidelines for proper diagnosing and treatment of this important complication.",

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AU - Plantaz, Dominique

AU - Simon, Thorsten

AU - Angelini, Paola

AU - Cama, Armando

AU - London, Wendy B.

AU - Kramer, Kim

AU - Katzenstein, Howard M.

AU - Tortori-Donati, Paolo

AU - Rossi, Andrea

AU - D'Angio, Giulio J.

AU - Evans, Audrey E.

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Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects

Abstract

Keywords

ASJC Scopus subject areas

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