Epidermal growth factor in cutaneous repair processes

G. Ricotti, M. G. Tucci, A. Pugnaloni, G. Biagini, A. Belligolli, A. Bertani, R. Castagnani, C. Castaldini

Research output: Contribution to journalArticlepeer-review


Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Morphometric analyses showed that cutaneous explants, treated with EGF, presented a higher number of microvessels (p <0.01) and mesenchimal cells (p <0.01), than untreated areas, while EGF did not improve epidermal thickening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.

Original languageEnglish
Pages (from-to)65-81
Number of pages17
JournalJournal of Bioactive and Compatible Polymers
Issue number1
Publication statusPublished - Jan 1992

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics


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