Epidermal growth factor in cutaneous repair processes

G. Ricotti; M. G. Tucci; A. Pugnaloni; G. Biagini; A. Belligolli; A. Bertani; R. Castagnani; C. Castaldini

Epidermal growth factor in cutaneous repair processes

G. Ricotti, M. G. Tucci, A. Pugnaloni, G. Biagini, A. Belligolli, A. Bertani, R. Castagnani, C. Castaldini

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Morphometric analyses showed that cutaneous explants, treated with EGF, presented a higher number of microvessels (p <0.01) and mesenchimal cells (p <0.01), than untreated areas, while EGF did not improve epidermal thickening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.

Original language	English
Pages (from-to)	65-81
Number of pages	17
Journal	Journal of Bioactive and Compatible Polymers
Volume	7
Issue number	1
Publication status	Published - Jan 1992

ASJC Scopus subject areas

Biotechnology
Biomaterials
Materials Chemistry
Polymers and Plastics

Cite this

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title = "Epidermal growth factor in cutaneous repair processes",

abstract = "Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Morphometric analyses showed that cutaneous explants, treated with EGF, presented a higher number of microvessels (p <0.01) and mesenchimal cells (p <0.01), than untreated areas, while EGF did not improve epidermal thickening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.",

author = "G. Ricotti and Tucci, {M. G.} and A. Pugnaloni and G. Biagini and A. Belligolli and A. Bertani and R. Castagnani and C. Castaldini",

year = "1992",

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T1 - Epidermal growth factor in cutaneous repair processes

AU - Ricotti, G.

AU - Tucci, M. G.

AU - Pugnaloni, A.

AU - Biagini, G.

AU - Belligolli, A.

AU - Bertani, A.

AU - Castagnani, R.

AU - Castaldini, C.

PY - 1992/1

Y1 - 1992/1

N2 - Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Morphometric analyses showed that cutaneous explants, treated with EGF, presented a higher number of microvessels (p <0.01) and mesenchimal cells (p <0.01), than untreated areas, while EGF did not improve epidermal thickening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.

AB - Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Morphometric analyses showed that cutaneous explants, treated with EGF, presented a higher number of microvessels (p <0.01) and mesenchimal cells (p <0.01), than untreated areas, while EGF did not improve epidermal thickening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.

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JO - Journal of Bioactive and Compatible Polymers

JF - Journal of Bioactive and Compatible Polymers

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Epidermal growth factor in cutaneous repair processes

Abstract

ASJC Scopus subject areas

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