Enterovirus D68-Associated Community-Acquired Pneumonia in the Pediatric Age Group

Samantha Bosis, Susanna Esposito

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: This review summarizes the current knowledge regarding the role of Enterovirus D68 (EV-D68) in community-acquired pneumonia (CAP) in children. Recent Findings: EV-D68 is an emergent viral pathogen. Since its first isolation in 1962 in California in four children suffering from CAP and bronchiolitis, EV-D68 has been rarely detected from respiratory specimens. However, recently, EV-D68 infection has raised concerns in the international community because of outbreaks in 2014 in the USA and the increased number of children with EV-D68-associated severe respiratory illnesses, including pneumonia, that have been reported in many other countries around the world. Summary: EV-D68 causes severe and life-threatening respiratory diseases in the pediatric population, particularly in children with underlying conditions such as prematurity or chronic diseases. Since no specific treatment or vaccinations are available for EV-D68 infections, greater surveillance as well as the use of sensitive and rapid diagnostic methods are essential to prevent and manage new outbreaks.

Original languageEnglish
Article number12
JournalCurrent Infectious Disease Reports
Issue number3
Publication statusPublished - Mar 1 2017


  • Children
  • Community-acquired pneumonia
  • Enterovirus D68
  • EV-D68
  • Respiratory distress
  • Respiratory tract infections

ASJC Scopus subject areas

  • Infectious Diseases


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