Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

Giovanna Liuzzo; Antonino Buffon; Luigi M. Biasucci; J. Ruth Gallimore; Giuseppina Caligiuri; Alessandra Vitelli; Sergio Altamura; Gennaro Ciliberto; Antonio G. Rebuzzi; Filippo Crea; Mark B. Pepys; Attilio Maseri

Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

Giovanna Liuzzo, Antonino Buffon, Luigi M. Biasucci, J. Ruth Gallimore, Giuseppina Caligiuri, Alessandra Vitelli, Sergio Altamura, Gennaro Ciliberto, Antonio G. Rebuzzi, Filippo Crea, Mark B. Pepys, Attilio Maseri

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B). Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography. In protocol A, baseline CRP, SAA, and IL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P

Original language	English
Pages (from-to)	2370-2376
Number of pages	7
Journal	Circulation
Volume	98
Issue number	22
Publication status	Published - Dec 1 1998

Keywords

Angina
Angioplasty
Interleukins
Plaque

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

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title = "Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina",

abstract = "Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B). Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography. In protocol A, baseline CRP, SAA, and IL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P",

keywords = "Angina, Angioplasty, Interleukins, Plaque",

author = "Giovanna Liuzzo and Antonino Buffon and Biasucci, {Luigi M.} and Gallimore, {J. Ruth} and Giuseppina Caligiuri and Alessandra Vitelli and Sergio Altamura and Gennaro Ciliberto and Rebuzzi, {Antonio G.} and Filippo Crea and Pepys, {Mark B.} and Attilio Maseri",

year = "1998",

month = dec,

day = "1",

language = "English",

volume = "98",

pages = "2370--2376",

journal = "Circulation",

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TY - JOUR

T1 - Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

AU - Liuzzo, Giovanna

AU - Buffon, Antonino

AU - Biasucci, Luigi M.

AU - Gallimore, J. Ruth

AU - Caligiuri, Giuseppina

AU - Vitelli, Alessandra

AU - Altamura, Sergio

AU - Ciliberto, Gennaro

AU - Rebuzzi, Antonio G.

AU - Crea, Filippo

AU - Pepys, Mark B.

AU - Maseri, Attilio

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B). Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography. In protocol A, baseline CRP, SAA, and IL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P

AB - Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B). Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography. In protocol A, baseline CRP, SAA, and IL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P

KW - Angina

KW - Angioplasty

KW - Interleukins

KW - Plaque

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M3 - Article

C2 - 9832480

AN - SCOPUS:0032401725

SN - 0009-7322

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JO - Circulation

JF - Circulation

IS - 22

ER -

Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

Abstract

Keywords

ASJC Scopus subject areas

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