Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role

Arianna Palladini; Annalisa Astolfi; Stefania Croci; Carla De Giovanni; Giordano Nicoletti; Angelo Rosolen; Francesca Sartori; Pier Luigi Lollini; Lorena Landuzzi; Patrizia Nanni

doi:10.1016/j.ejca.2005.11.024

Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role

Arianna Palladini, Annalisa Astolfi, Stefania Croci, Carla De Giovanni, Giordano Nicoletti, Angelo Rosolen, Francesca Sartori, Pier Luigi Lollini, Lorena Landuzzi, Patrizia Nanni

Research output: Contribution to journal › Article › peer-review

Abstract

Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.

Original language	English
Pages (from-to)	680-687
Number of pages	8
Journal	European Journal of Cancer
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.ejca.2005.11.024
Publication status	Published - Mar 2006

Keywords

Angiogenesis
Endothelin-3
Paracrine factors
Rhabdomyosarcoma

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.ejca.2005.11.024

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title = "Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role",

abstract = "Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.",

keywords = "Angiogenesis, Endothelin-3, Paracrine factors, Rhabdomyosarcoma",

author = "Arianna Palladini and Annalisa Astolfi and Stefania Croci and {De Giovanni}, Carla and Giordano Nicoletti and Angelo Rosolen and Francesca Sartori and Lollini, {Pier Luigi} and Lorena Landuzzi and Patrizia Nanni",

year = "2006",

month = mar,

doi = "10.1016/j.ejca.2005.11.024",

language = "English",

volume = "42",

pages = "680--687",

journal = "European Journal of Cancer",

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T2 - A possible new marker with a paracrine role

AU - Palladini, Arianna

AU - Astolfi, Annalisa

AU - Croci, Stefania

AU - De Giovanni, Carla

AU - Nicoletti, Giordano

AU - Rosolen, Angelo

AU - Sartori, Francesca

AU - Lollini, Pier Luigi

AU - Landuzzi, Lorena

AU - Nanni, Patrizia

PY - 2006/3

Y1 - 2006/3

N2 - Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.

AB - Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.

KW - Angiogenesis

KW - Endothelin-3

KW - Paracrine factors

KW - Rhabdomyosarcoma

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ER -

Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role

Abstract

Keywords

ASJC Scopus subject areas

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