eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54

Rosalba Rosato; Silvia Testa; Antonio Bertolotto; Francesco Scavelli; Ambra M Giovannetti; Paolo Confalonieri; Francesco Patti; Clara Grazia Chisari; Alessandra Lugaresi; Erika Pietrolongo; Maria Grazia Grasso; Ilaria Rossi; Anna Toscano; Barbara Loera; Andrea Giordano; Alessandra Solari

doi:10.1177/1352458518774935

eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54

Rosalba Rosato, Silvia Testa, Antonio Bertolotto, Francesco Scavelli, Ambra M Giovannetti, Paolo Confalonieri, Francesco Patti, Clara Grazia Chisari, Alessandra Lugaresi, Erika Pietrolongo, Maria Grazia Grasso, Ilaria Rossi, Anna Toscano, Barbara Loera, Andrea Giordano, Alessandra Solari

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29).

OBJECTIVES: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29.

METHODS: Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0-9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design).

RESULTS: 'Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88-0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good.

CONCLUSION: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.

Original language	English
Pages (from-to)	1352458518774935
Journal	Multiple Sclerosis
DOIs	https://doi.org/10.1177/1352458518774935
Publication status	E-pub ahead of print - May 1 2018

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Rosato, R., Testa, S., Bertolotto, A., Scavelli, F., Giovannetti, A. M., Confalonieri, P., Patti, F., Chisari, C. G., Lugaresi, A., Pietrolongo, E., Grasso, M. G., Rossi, I., Toscano, A., Loera, B., Giordano, A., & Solari, A. (2018). eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54. Multiple Sclerosis, 1352458518774935. https://doi.org/10.1177/1352458518774935

Rosato, R, Testa, S, Bertolotto, A, Scavelli, F, Giovannetti, AM, Confalonieri, P, Patti, F, Chisari, CG, Lugaresi, A, Pietrolongo, E, Grasso, MG, Rossi, I, Toscano, A, Loera, B, Giordano, A & Solari, A 2018, 'eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54', Multiple Sclerosis, pp. 1352458518774935. https://doi.org/10.1177/1352458518774935

@article{a9429f8c6d074c60b648957d57d01099,

title = "eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54",

abstract = "BACKGROUND: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29).OBJECTIVES: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29.METHODS: Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0-9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design).RESULTS: 'Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88-0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good.CONCLUSION: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.",

author = "Rosalba Rosato and Silvia Testa and Antonio Bertolotto and Francesco Scavelli and Giovannetti, {Ambra M} and Paolo Confalonieri and Francesco Patti and Chisari, {Clara Grazia} and Alessandra Lugaresi and Erika Pietrolongo and Grasso, {Maria Grazia} and Ilaria Rossi and Anna Toscano and Barbara Loera and Andrea Giordano and Alessandra Solari",

year = "2018",

month = may,

day = "1",

doi = "10.1177/1352458518774935",

language = "English",

pages = "1352458518774935",

journal = "Multiple Sclerosis",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - eMSQOL-29

T2 - Prospective validation of the abbreviated, electronic version of MSQOL-54

AU - Rosato, Rosalba

AU - Testa, Silvia

AU - Bertolotto, Antonio

AU - Scavelli, Francesco

AU - Giovannetti, Ambra M

AU - Confalonieri, Paolo

AU - Patti, Francesco

AU - Chisari, Clara Grazia

AU - Lugaresi, Alessandra

AU - Pietrolongo, Erika

AU - Grasso, Maria Grazia

AU - Rossi, Ilaria

AU - Toscano, Anna

AU - Loera, Barbara

AU - Giordano, Andrea

AU - Solari, Alessandra

PY - 2018/5/1

Y1 - 2018/5/1

N2 - BACKGROUND: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29).OBJECTIVES: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29.METHODS: Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0-9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design).RESULTS: 'Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88-0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good.CONCLUSION: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.

AB - BACKGROUND: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29).OBJECTIVES: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29.METHODS: Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0-9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design).RESULTS: 'Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88-0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good.CONCLUSION: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.

U2 - 10.1177/1352458518774935

DO - 10.1177/1352458518774935

M3 - Article

C2 - 29761738

SN - 1352-4585

SP - 1352458518774935

JO - Multiple Sclerosis

JF - Multiple Sclerosis

ER -

eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54

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