TY - JOUR
T1 - Embryopathy Following Maternal Biliopancreatic Diversion
T2 - Is Bariatric Surgery Really Safe?
AU - Onesimo, Roberta
AU - Proli, Francesco
AU - Leoni, Chiara
AU - Contaldo, Ilaria
AU - Salerni, Annabella
AU - Conti, Guido
AU - Tartaglia, Marco
AU - Zampino, Giuseppe
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/1
Y1 - 2021/1
N2 - Pregnancy after bariatric surgery is usually considered safe. Recently, a few studies reported that bariatric surgery represents a risk factor for birth defects. A case series of six patients, born from women who had undergone biliopancreatic diversion, is reported. The clinical pattern was characterized by psychomotor development delay (100%), microphthalmia (83%), growth retardation (66%), hearing loss (66%), and variable facial dysmorphism. Based on the clinical profile and symptoms reported by women during pregnancy, a causal association between maternal chronic post-surgical malabsorption, congenital anomalies, and neonatal outcome is proposed, with vitamin A deficiency representing a major causing factor. Educational follow-up support, continuous clinical monitoring, and appropriate nutritional assessment appear to be crucial to reduce the potential risk of congenital malformations and child disability.
AB - Pregnancy after bariatric surgery is usually considered safe. Recently, a few studies reported that bariatric surgery represents a risk factor for birth defects. A case series of six patients, born from women who had undergone biliopancreatic diversion, is reported. The clinical pattern was characterized by psychomotor development delay (100%), microphthalmia (83%), growth retardation (66%), hearing loss (66%), and variable facial dysmorphism. Based on the clinical profile and symptoms reported by women during pregnancy, a causal association between maternal chronic post-surgical malabsorption, congenital anomalies, and neonatal outcome is proposed, with vitamin A deficiency representing a major causing factor. Educational follow-up support, continuous clinical monitoring, and appropriate nutritional assessment appear to be crucial to reduce the potential risk of congenital malformations and child disability.
KW - Biliopancreatic diversion
KW - Embryopathy
KW - Nutrition
KW - Obesity surgery safeness
KW - Vitamin A deficiency
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U2 - 10.1007/s11695-020-04882-w
DO - 10.1007/s11695-020-04882-w
M3 - Article
C2 - 32720264
AN - SCOPUS:85088582402
SN - 0960-8923
VL - 31
SP - 445
EP - 450
JO - Obesity Surgery
JF - Obesity Surgery
IS - 1
ER -