Embriopatía por isotretinoína: Una entidad que puede evitarse

Francisco Cammarata-Scalisi; Dairelis Nieves; Andrea Avendaño; María A Lacruz-Rengel; Karelys Alviárez; Francys Dávila; Izzet Yavuz; Michele Callea

doi:10.5546/aap.2018.e303

Embriopatía por isotretinoína: Una entidad que puede evitarse

Translated title of the contribution: Isotretinoin embryopathy: An entity that can be avoided

Francisco Cammarata-Scalisi, Dairelis Nieves, Andrea Avendaño, María A Lacruz-Rengel, Karelys Alviárez, Francys Dávila, Izzet Yavuz, Michele Callea

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Isotretinoin is the most effective drug in the treatment of severe recalcitrant nodulocystic acne. However, treatment with this drug is associated with adverse effects, the most severe being teratogenesis. It has been estimated that 40% of pregnancies exposed to isotretinoin present spontaneous abortion and 35% develop embryopathy. We present the case of a newborn with a history of prenatal exposure to isotretinoin, a clinical entity that can be avoided, with severe congenital defects in the central nervous system and important facial dysmorphisms, with unfavorable clinical course.

Translated title of the contribution	Isotretinoin embryopathy: An entity that can be avoided
Original language	Spanish
Pages (from-to)	e303-e307
Number of pages	5
Journal	Archivos Argentinos de Pediatria
Volume	116
Issue number	2
DOIs	https://doi.org/10.5546/aap.2018.e303
Publication status	Published - Apr 1 2018

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title = "Embriopat{\'i}a por isotretino{\'i}na: Una entidad que puede evitarse",

abstract = "Isotretinoin is the most effective drug in the treatment of severe recalcitrant nodulocystic acne. However, treatment with this drug is associated with adverse effects, the most severe being teratogenesis. It has been estimated that 40% of pregnancies exposed to isotretinoin present spontaneous abortion and 35% develop embryopathy. We present the case of a newborn with a history of prenatal exposure to isotretinoin, a clinical entity that can be avoided, with severe congenital defects in the central nervous system and important facial dysmorphisms, with unfavorable clinical course.",

author = "Francisco Cammarata-Scalisi and Dairelis Nieves and Andrea Avenda{\~n}o and Lacruz-Rengel, {Mar{\'i}a A} and Karelys Alvi{\'a}rez and Francys D{\'a}vila and Izzet Yavuz and Michele Callea",

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doi = "10.5546/aap.2018.e303",

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T1 - Embriopatía por isotretinoína

T2 - Una entidad que puede evitarse

AU - Cammarata-Scalisi, Francisco

AU - Nieves, Dairelis

AU - Avendaño, Andrea

AU - Lacruz-Rengel, María A

AU - Alviárez, Karelys

AU - Dávila, Francys

AU - Yavuz, Izzet

AU - Callea, Michele

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AB - Isotretinoin is the most effective drug in the treatment of severe recalcitrant nodulocystic acne. However, treatment with this drug is associated with adverse effects, the most severe being teratogenesis. It has been estimated that 40% of pregnancies exposed to isotretinoin present spontaneous abortion and 35% develop embryopathy. We present the case of a newborn with a history of prenatal exposure to isotretinoin, a clinical entity that can be avoided, with severe congenital defects in the central nervous system and important facial dysmorphisms, with unfavorable clinical course.

U2 - 10.5546/aap.2018.e303

DO - 10.5546/aap.2018.e303

M3 - Articolo

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SN - 0325-0075

VL - 116

SP - e303-e307

JO - Archivos Argentinos de Pediatria

JF - Archivos Argentinos de Pediatria

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ER -

Embriopatía por isotretinoína: Una entidad que puede evitarse

Abstract

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