Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease

Fenne Margreeth Smits; Camillo Porcaro; Carlo Cottone; Andrea Cancelli; Paolo Maria Rossini; Franca Tecchio

doi:10.1371/journal.pone.0149587

Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease

Fenne Margreeth Smits, Camillo Porcaro, Carlo Cottone, Andrea Cancelli, Paolo Maria Rossini, Franca Tecchio

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Brain activity is complex; a reflection of its structural and functional organization. Among other measures of complexity, the fractal dimension is emerging as being sensitive to neuronal damage secondary to neurological and psychiatric diseases. Here, we calculated Higuchi's fractal dimension (HFD) in resting-state eyes-closed electroencephalography (EEG) recordings from 41 healthy controls (age: 20-89 years) and 67 Alzheimer's Disease (AD) patients (age: 50-88 years), to investigate whether HFD is sensitive to brain activity changes typical in healthy aging and in AD. Additionally, we considered whether AD-accelerating effects of the copper fraction not bound to ceruloplasmin (also called "free" copper) are reflected in HFD fluctuations. The HFD measure showed an inverted U-shaped relationship with age in healthy people (R²=.575, p

Original language	English
Article number	e0149587
Journal	PLoS One
Volume	11
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0149587
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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AU - Porcaro, Camillo

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AU - Cancelli, Andrea

AU - Rossini, Paolo Maria

AU - Tecchio, Franca

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Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease

Abstract

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