Efficacy of placebo in the treatment of patients with amenorrhea

P. G. Crosignani, A. M. Mattei, P. Maggioni, G. Testa, E. Negri

Research output: Contribution to journalArticlepeer-review


Thirty-two amenorrheic patients were treated with a tablet oral placebo preparation for a period varying from 30 to 180 days. Another 24 amenorrheic patients were also treated with a placebo administered i.m. for a period varying from 30 to 120 days. As a consequence of the treatment, 27 patients (48%) had menstrual bleedings. The progestogen withdrawal test responsive patients were more responsive to placebo (73 vs. 14% in the progestogen withdrawal test nonresponsive, p <0.001). The time lag between starting the medication and the first bleeding varied between 4 and 120 days with a mean value of 33.9 (SD 26.3). Oral placebo was more effective than the intramuscular form (56 vs. 38%, p <0.05).

Original languageEnglish
Pages (from-to)183-184
Number of pages2
JournalGynecologic and Obstetric Investigation
Issue number3
Publication statusPublished - 1994


  • Amenorrhea
  • Hypothalamus
  • Placebo

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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